• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

知情同意:临床试验视角

Informed Consent: A Clinical Trials Perspective.

作者信息

Hammer Marilyn J, Eckardt Patricia, Barton-Burke Margaret

机构信息

College of Nursing, New York University in New York.

Rockefeller University.

出版信息

Oncol Nurs Forum. 2016 Nov 1;43(6):694-696. doi: 10.1188/16.ONF.694-696.

DOI:10.1188/16.ONF.694-696
PMID:27768140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5637387/
Abstract

The primary goal of the thousands of registered trials in cancer research is to extend survival. With evaluation of efficacy, safety, and tolerability, healthcare providers must ensure that the principles described in the Belmont Report are upheld and that patients are truly informed when signing a consent form. In this article, two cases are highlighted, and reasons for participating in clinical trials are discussed. Challenges, such as healthcare literacy, patients' dedication to their healthcare providers, and choosing between multiple trials, are also explored.

摘要

癌症研究中数千项注册试验的主要目标是延长生存期。在评估疗效、安全性和耐受性时,医疗保健提供者必须确保坚持《贝尔蒙报告》中所述的原则,并确保患者在签署同意书时得到真正的告知。本文突出了两个案例,并讨论了参与临床试验的原因。还探讨了一些挑战,如医疗保健素养、患者对其医疗保健提供者的忠诚度以及在多个试验之间进行选择等。

相似文献

1
Informed Consent: A Clinical Trials Perspective.知情同意:临床试验视角
Oncol Nurs Forum. 2016 Nov 1;43(6):694-696. doi: 10.1188/16.ONF.694-696.
2
Valid informed consent in research: an introduction.研究中的有效知情同意:引言
Br J Nurs. 2014;23(11):564-7. doi: 10.12968/bjon.2014.23.11.564.
3
[Deontological guidelines applicable to nursing research].适用于护理研究的道义论准则
Rech Soins Infirm. 1996 Dec(47):67-72.
4
The interplay between the abstract and the particular: research ethics standards and the practice of research as symbolic.抽象与具体之间的相互作用:研究伦理标准与作为象征性的研究实践
Nurs Sci Q. 2006 Jan;19(1):20-4; discussion 19. doi: 10.1177/0894318405284122.
5
Tools for the advancement of quality care.提升优质护理的工具。
Semin Oncol Nurs. 2004 May;20(2):89-100, table of contents. doi: 10.1053/j.soncn.2004.02.003.
6
The length of consent documents in oncological trials is doubled in twenty years.肿瘤学试验中知情同意书的长度在二十年内增加了一倍。
Ann Oncol. 2009 Feb;20(2):379-85. doi: 10.1093/annonc/mdn623. Epub 2008 Oct 15.
7
American Society of Clinical Oncology policy statement: oversight of clinical research.美国临床肿瘤学会政策声明:临床研究监督
J Clin Oncol. 2003 Jun 15;21(12):2377-86. doi: 10.1200/JCO.2003.04.026. Epub 2003 Apr 29.
8
Informed Consent in the Changing Landscape of Research.研究格局变化中的知情同意
Oncol Nurs Forum. 2016 Sep 1;43(5):558-60. doi: 10.1188/16.ONF.558-560.
9
The oncology nurse's role in the informed consent process.
Oncology (Williston Park). 2007 Jul;21(8 Suppl):11-4; discussion 15.
10
The Royal College of Nursing Research Society: nurses and research ethics.皇家护理学院研究学会:护士与研究伦理
Nurse Res. 2003;11(1):7-21.

引用本文的文献

1
Gene-Based Therapeutics for Parkinson's Disease.帕金森病的基因疗法
Biomedicines. 2022 Jul 26;10(8):1790. doi: 10.3390/biomedicines10081790.
2
CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future.CRISPR基因疗法:应用、局限性及对未来的启示
Front Oncol. 2020 Aug 7;10:1387. doi: 10.3389/fonc.2020.01387. eCollection 2020.

本文引用的文献

1
Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program.瑞戈非尼用于标准治疗难治性转移性结直肠癌患者的生存、安全性及预后因素:一项嵌套于同情用药项目中的多中心研究(REBECCA)结果
BMC Cancer. 2016 Jul 7;16:412. doi: 10.1186/s12885-016-2440-9.
2
Challenges in translating endpoints from trials to observational cohort studies in oncology.肿瘤学中从试验终点向观察性队列研究终点转换的挑战。
Clin Epidemiol. 2016 Jun 11;8:195-200. doi: 10.2147/CLEP.S97874. eCollection 2016.
3
The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research.《贝尔蒙报告》。保护人类研究受试者的伦理原则与准则。
J Am Coll Dent. 2014 Summer;81(3):4-13.
4
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.嵌合抗原受体修饰的 T 细胞治疗慢性淋巴细胞白血病。
N Engl J Med. 2011 Aug 25;365(8):725-33. doi: 10.1056/NEJMoa1103849. Epub 2011 Aug 10.
5
The death of Jesse Gelsinger: new evidence of the influence of money and prestige in human research.杰西·盖辛格之死:金钱与声望对人体研究影响的新证据。
Am J Law Med. 2010;36(2-3):295-325. doi: 10.1177/009885881003600202.
6
Gene therapy: trials and tribulations.基因治疗:试验与磨难
Nat Rev Genet. 2000 Nov;1(2):91-9. doi: 10.1038/35038533.