癌症中的p62：自噬之外的信号衔接蛋白
p62 in Cancer: Signaling Adaptor Beyond Autophagy.
作者信息
Moscat Jorge, Karin Michael, Diaz-Meco Maria T
机构信息
Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Laboratory of Signal Transduction and Gene Regulation Departments of Pharmacology and Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla Ca 92093, USA.
出版信息
Cell. 2016 Oct 20;167(3):606-609. doi: 10.1016/j.cell.2016.09.030.
Abstract
Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.
摘要
衔接蛋白参与选择性自噬，这对细胞解毒和缓解应激至关重要。然而，新证据支持衔接蛋白p62（由基因Sqstm1编码）在不依赖自噬的情况下，在上皮细胞肿瘤起始和基质中肿瘤进展抑制的核心信号功能中发挥关键作用。
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Cancer Cell. 2016 Jun 13;29(6):935-948. doi: 10.1016/j.ccell.2016.04.006. Epub 2016 May 19.
2
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.核因子-κB通过清除受损线粒体来限制炎性小体激活。
Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057.
3
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Cancer Cell. 2015 Apr 13;27(4):462-72. doi: 10.1016/j.ccell.2015.02.015. Epub 2015 Apr 6.
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8
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Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition.持续性mTORC1抑制后出现肝损伤、炎症及肿瘤发生增强。
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