Hecht B R, Khan-Dawood F S, Dawood M Y
Department of Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago 60612.
Fertil Steril. 1989 Sep;52(3):401-5. doi: 10.1016/s0015-0282(16)60907-x.
Clomiphene citrate (CC) has been used to influence the timing of ovulation. To evaluate the effects of CC on the timing of the luteinizing hormone (LH) surge, we examined the LH surge in 10 cycling normal women for 3 cycles each, during an untreated cycle (control) and during treatment with 50 mg CC (CC 50) and 150 mg CC (CC 150) daily on days 5 to 9. Length of control cycles (mean +/- standard error of the mean) was 28.5 +/- 1.1 days and was not significantly different from either CC 50 (28.2 +/- 0.6 days) or CC 150 cycles (29.0 +/- 0.4 days). LH surge occurred on day 16.4 +/- 1.2 in control, 16.5 +/- 0.5 in CC 50, and 17.1 +/- 0.7 in CC 150 cycles. Similarly, luteal phase lengths were not significantly affected by CC treatment. Individually, however, the effect of CC on the timing of the LH surge depended on when the LH surge occurred in corresponding control cycles. If the control cycle LH surge occurred on day 16 or earlier, CC significantly delayed it. If the normal LH surge occurred on day 18 or later, CC advanced it. During CC 50 treatment, the LH surge was advanced by 1 to 7 days in 3 cycles, unchanged in 2, and delayed in 5 cycles by 1 to 9 days. Detection of urinary LH surge was reliable in CC-treated cycles and correlated well with the day of plasma LH surge.(ABSTRACT TRUNCATED AT 250 WORDS)
枸橼酸氯米芬（CC）已被用于影响排卵时间。为了评估CC对促黄体生成素（LH）峰出现时间的影响，我们对10名月经周期正常的女性进行了研究，每人观察3个周期，分别为未治疗周期（对照）以及在第5至9天每天服用50 mg CC（CC 50）和150 mg CC（CC 150）的治疗周期。对照周期的长度（平均值±平均标准误差）为28.5±1.1天，与CC 50周期（28.2±0.6天）或CC 150周期（29.0±0.4天）相比无显著差异。LH峰在对照周期的第16.4±1.2天出现，在CC 50周期为16.5±0.5天，在CC 150周期为17.1±0.7天。同样，黄体期长度也未受到CC治疗的显著影响。然而，就个体而言，CC对LH峰出现时间的影响取决于LH峰在相应对照周期中出现的时间。如果对照周期的LH峰在第16天或更早出现，CC会使其显著延迟。如果正常的LH峰在第18天或更晚出现，CC会使其提前。在CC 50治疗期间，3个周期的LH峰提前了1至7天，2个周期无变化，5个周期延迟了1至9天。在CC治疗的周期中，尿LH峰的检测是可靠的，并且与血浆LH峰出现的日期相关性良好。（摘要截短于250字）
