Massey J B, Ingargiola P E, Tucker M J, Mitchell-Leef D E, Wright G
Reproductive Biology Associates, Atlanta, Georgia 30342, USA.
J Assist Reprod Genet. 1994 Aug;11(7):353-8. doi: 10.1007/BF02214141.
This retrospective, descriptive study was designed to determine the effectiveness of using clomiphene citrate in relatively high daily doses (100, 150, and 200 mg) with simplified monitoring for in vitro fertilization in a private office and surgical center. The self-selected study population comprised 109 women who were 25-42 years old, including 26 women whose husbands had mild male-factor infertility.
During January 1992 through December 1993, 165 stimulation cycles resulted in 137 egg retrievals, 24 clinical pregnancies (17.5%), and 20 viable pregnancies (14.5%). Cycles that could not be completed (28/165 or 16.9% of all cycles) involved luteinizing hormone surges, insufficient follicles, or low estradiol levels. There were no pregnancies in patients who were 40 years or older or who received 200 mg daily doses of clomiphene citrate. The viable pregnancy rate among patients with male factor infertility was 7.7% (2/26). For non-male-factor infertility patients who were younger than 40, the viable pregnancy rate was 17.6% (18/102).
The simplified monitoring method did not appear to compromise the results.
本回顾性描述性研究旨在确定在私人诊所和手术中心使用相对高剂量（100、150和200毫克）枸橼酸氯米芬并简化监测用于体外受精的有效性。自行选择的研究人群包括109名年龄在25至42岁之间的女性，其中26名女性的丈夫患有轻度男性因素不孕症。
在1992年1月至1993年12月期间，165个刺激周期导致137次取卵、24例临床妊娠（17.5%）和20例活产妊娠（14.5%）。无法完成的周期（28/165或所有周期的16.9%）涉及促黄体生成素激增、卵泡不足或雌二醇水平低。40岁及以上的患者或每天接受200毫克枸橼酸氯米芬剂量的患者均未怀孕。男性因素不孕症患者的活产妊娠率为7.7%（2/26）。对于年龄小于40岁的非男性因素不孕症患者，活产妊娠率为17.6%（18/102）。
简化的监测方法似乎并未影响结果。
