纤连蛋白-3对恶性胸膜间皮瘤的诊断价值：一项系统评价和荟萃分析。
Diagnostic value of fibulin-3 for malignant pleural mesothelioma: A systematic review and meta-analysis.
作者信息
Ren Ran, Yin Pengpeng, Zhang Yan, Zhou Jianyun, Zhou Yixing, Xu Rufu, Lin Hai, Huang Chunji
机构信息
Division of Scientific Research, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.
Department of Scientific Research, Third Military Medical University, Chongqing, 400038, China.
出版信息
Oncotarget. 2016 Dec 20;7(51):84851-84859. doi: 10.18632/oncotarget.12707.
BACKGROUND
Several studies have investigated the diagnostic value of fibulin-3 for malignant pleural mesothelioma (MPM), but the results were various. Therefore, we performed a systematic review and meta-analysis to evaluate the diagnostic value of fibulin-3 for MPM.
RESULTS
Eight studies were included in this work. The overall sensitivity of blood fibulin-3 were 0.87 (95% CI, 0.58 - 0.97) and 0.89 (95% CI, 0.77 - 0.95), respectively. The overall sensitivity and specificity of PF fibulin-3 for MPM were 0.73 (95% CI, 0.54 - 0.86) and 0.80 (95% CI, 0.60 - 0.91), respectively. The area under curve of blood and pleural effusion (PF) Fibulin-3 were 0.94 (95% CI, 0.91 - 0.96) 0.83 (95% CI, 0.79 - 0.86), respectively.
METHODS
PubMed and EMBASE databases were searched up to July 29, 2016 to verify studies investigating the diagnostic value of fibulin-3 for MPM. The quality of eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy tool (QUADAS-2). The overall sensitivity and specificity were pooled using a bivariate model.
CONCLUSION
Fibuoin-3 is a useful diagnostic marker for MPM.
背景
多项研究探讨了纤维连接蛋白-3对恶性胸膜间皮瘤（MPM）的诊断价值，但结果各异。因此，我们进行了一项系统评价和荟萃分析，以评估纤维连接蛋白-3对MPM的诊断价值。
结果
本研究纳入了8项研究。血液中纤维连接蛋白-3的总体敏感性分别为0.87（95%可信区间，0.58 - 0.97）和0.89（95%可信区间，0.77 - 0.95）。MPM的胸腔积液（PF）中纤维连接蛋白-3的总体敏感性和特异性分别为0.73（95%可信区间，0.54 - 0.86）和0.80（95%可信区间，0.60 - 0.91）。血液和胸腔积液（PF）中纤维连接蛋白-3的曲线下面积分别为0.94（95%可信区间，0.91 - 0.96）和0.83（95%可信区间，0.79 - 0.86）。
方法
检索截至2016年7月29日的PubMed和EMBASE数据库，以核实关于纤维连接蛋白-3对MPM诊断价值的研究。使用修订后的诊断准确性研究质量评估工具（QUADAS-2）评估符合条件研究的质量。采用双变量模型汇总总体敏感性和特异性。
结论
纤维连接蛋白-3是MPM的一种有用诊断标志物。
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