TRIM24对人类癌症中基因表达的调控

Regulation of gene expression in human cancers by TRIM24.

作者信息

Appikonda Srikanth, Thakkar Kaushik N, Barton Michelle Craig

机构信息

Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, Houston, TX 77030, USA.

Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, Houston, TX 77030, USA; University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Drug Discov Today Technol. 2016 Mar;19:57-63. doi: 10.1016/j.ddtec.2016.05.001. Epub 2016 Aug 10.

DOI:10.1016/j.ddtec.2016.05.001

PMID:27769359

Abstract

Tripartite Motif-containing protein 24 (TRIM24) functions as an E3 ligase targeting p53 for ubiquitination, a histone 'reader' that interacts with a specific signature of histone post-translational modifications and a co-regulator of nuclear receptor-regulated transcription. Although mouse models of Trim24 depletion suggest that TRIM24 may be a liver-specific tumor suppressor, several studies show that human TRIM24 is an oncogene when aberrantly over expressed. This review focuses on the mechanisms of TRIM24 functions in oncogenesis and metabolic reprogramming, which underlie recent interest in therapeutic targeting of aberrant TRIM24 in human cancers.

摘要

含三联基序蛋白24（TRIM24）作为一种E3连接酶，靶向p53进行泛素化修饰，是一种与组蛋白翻译后修饰的特定特征相互作用的组蛋白“阅读器”，也是核受体调节转录的共调节因子。尽管Trim24基因敲除的小鼠模型表明TRIM24可能是肝脏特异性肿瘤抑制因子，但多项研究表明，人TRIM24异常过表达时是一种癌基因。本综述重点关注TRIM24在肿瘤发生和代谢重编程中的作用机制，这些机制是近期人们对在人类癌症中异常TRIM24进行治疗靶向研究感兴趣的基础。