非洲爪蟾中抑制功能的环磷酰胺敏感性差异
Differential cyclophosphamide sensitivity of suppressor function in Xenopus, the clawed toad.
作者信息
Clothier R H, Last Z, Somauroo J D, Ruben L N, Balls M
机构信息
Department of Human Morphology, University of Nottingham, Queen's Medical Centre, UK.
出版信息
Dev Comp Immunol. 1989 Spring;13(2):159-66. doi: 10.1016/0145-305x(89)90030-x.
Thymocyte and Splenocyte cultures from in vivo immunised Xenopus were assayed to test their suppressive capacity. Immunisation with TNP-Polyvinylpyrrolidone induced suppression. Suppression induced by the haptenated antigens, TNP-Red blood cells, TNP-Lipopolysaccharide, and TNP-Ficoll affected the anti-TNP antibody response of splenocytes from TNP-PVP immunised animals. Pretreatment with cyclophosphamide revealed both a sensitive and insensitive suppression capacity in Xenopus laevis.
对体内免疫的非洲爪蟾的胸腺细胞和脾细胞培养物进行检测，以测试它们的抑制能力。用三硝基苯 - 聚乙烯吡咯烷酮免疫可诱导抑制作用。由半抗原化抗原（三硝基苯 - 红细胞、三硝基苯 - 脂多糖和三硝基苯 - 聚蔗糖）诱导的抑制作用影响了来自三硝基苯 - 聚乙烯吡咯烷酮免疫动物的脾细胞的抗三硝基苯抗体反应。用环磷酰胺预处理显示非洲爪蟾既有敏感的抑制能力，也有不敏感的抑制能力。
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