非洲爪蟾对胸腺非依赖性抗原聚乙烯吡咯烷酮（PVP）及其半抗原化衍生物三硝基苯基化聚乙烯吡咯烷酮（TNP-PVP）的反应。

Responses in Xenopus to the thymus independent antigen polyvinylpyrrolidone (PVP) and its haptenated derivative, trinitrophenylated PVP (TNP-PVP).

作者信息

Clothier R H, Kandola L, Mirchandani M, Ellis A, Wood P, Last Z, Balls M, Ruben L N

机构信息

Department of Human Morphology, University of Nottingham Medical School, U.K.

出版信息

Cell Differ. 1988 Apr;23(3):213-20. doi: 10.1016/0045-6039(88)90074-7.

DOI:10.1016/0045-6039(88)90074-7

PMID:3378271

Abstract

Xenopus laevis (the South African clawed toad) can respond to thymus dependent (TD) and thymus independent (TI) antigens. However, the response to trinitrophenylated Ficoll (TNP-Ficoll), a TI-2 antigen in mammals, is thymus dependent in Xenopus. Polyvinylpyrrolidone (PVP), classed as a TI antigen in mammals, is also a TI antigen in Xenopus, but responses to PVP and TNP-PVP are thymus regulated. As with TNP-Ficoll, capacity to respond to TNP-PVP diminishes during metamorphosis, and tolerance can be induced via the stimulation of TD suppression with trinitrobenzene sulphonic acid. Animals treated with N-methyl-N-nitrosourea and adult-thymectomised Xenopus, which lack certain TD responses, can nevertheless respond to TNP-PVP. Based on this and other information, it is concluded that TNP-PVP should be classed as a TI-2 antigen in Xenopus.

摘要

非洲爪蟾（南非爪蟾）能够对胸腺依赖性（TD）抗原和非胸腺依赖性（TI）抗原产生反应。然而，在哺乳动物中作为TI-2抗原的三硝基苯化聚蔗糖（TNP-Ficoll），在非洲爪蟾中引发的反应却是胸腺依赖性的。在哺乳动物中归类为TI抗原的聚乙烯吡咯烷酮（PVP），在非洲爪蟾中也是TI抗原，但对PVP和TNP-PVP的反应受胸腺调节。与TNP-Ficoll一样，对TNP-PVP的反应能力在变态过程中会减弱，并且可以通过用三硝基苯磺酸刺激TD抑制来诱导耐受性。用N-甲基-N-亚硝基脲处理的动物以及成年胸腺切除的非洲爪蟾缺乏某些TD反应，但仍能对TNP-PVP产生反应。基于此及其他信息，得出结论：TNP-PVP在非洲爪蟾中应归类为TI-2抗原。