Institut de recherches cliniques de Montréal, Montréal, Québec, H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec, H3T 1A8, Canada.
Institut de recherches cliniques de Montréal, Montréal, Québec, H2W 1R7, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, H3T 1J4, Canada.
Clin Nutr. 2017 Dec;36(6):1580-1585. doi: 10.1016/j.clnu.2016.10.002. Epub 2016 Oct 8.
BACKGROUND & AIMS: Vitamin D (Vit D) deficiency in cystic fibrosis (CF) is partially secondary to exocrine pancreatic insufficiency. Our aim was to establish a Vit D supplementation protocol that will increase 25(OH)D to the recommended level (30 ng/mL).
Retrospective study of 200 patients (≥18 years) conducted from February 2007 to June 2014 at the CF clinic of the Centre Hospitalier de l'Université de Montréal. Vit D supplementation protocol was 1600 IU/day or 10,000 IU/week during the summer (May 1st to October 31st) and 3200 IU/day or 20,000 IU/week during the winter (November 1st to April 30th), in addition to the 1200 IU/day included in multivitamins.
Significant increase in serum 25(OH)D levels from baseline (25.9 ± 10.3 ng/mL) to follow-up (37.0 ± 11.4 ng/mL) (P ≤ 0.001). At follow-up, increased doses during the winter improved serum 25(OH)D levels to a degree comparable to the summer.
This supplementation protocol is efficient and needs to be tested in other CF adult cohorts and correlated to potential health benefit measurements.
囊性纤维化（CF）患者的维生素 D（Vit D）缺乏部分是由外分泌胰腺功能不全引起的。我们的目的是建立一个 Vit D 补充方案，将 25（OH）D 提高到推荐水平（30ng/mL）。
对 200 例（≥18 岁）患者进行回顾性研究，这些患者于 2007 年 2 月至 2014 年 6 月在蒙特利尔大学中心医院的 CF 诊所进行。Vit D 补充方案为 1600IU/天或 10000IU/周（5 月 1 日至 10 月 31 日）和 3200IU/天或 20000IU/周（11 月 1 日至 4 月 30 日），此外，复合维生素中还包含 1200IU/天的 Vit D。
血清 25（OH）D 水平从基线（25.9±10.3ng/mL）到随访（37.0±11.4ng/mL）显著升高（P≤0.001）。在随访时，冬季增加剂量可使血清 25（OH）D 水平提高到与夏季相当的程度。
该补充方案有效，需要在其他 CF 成年患者队列中进行测试，并与潜在的健康获益测量相关联。
