Aziz Danish Abdul, Fatima Syeda Khadija, Iftikhar Haissan, Mir Fatima
Department of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Department of otorhinolaryngology, Aga Khan University Hospital, Karachi, Pakistan.
Lung India. 2021 Jul-Aug;38(4):326-329. doi: 10.4103/lungindia.lungindia_589_20.
The function of Vitamin D in preventing inflammation and infection has been studied previously for different pathologies in different populations globally. Relationships between serum Vitamin D levels and its effect on pulmonary exacerbations in the cystic fibrosis (CF) population are not well studied in our part of the world. Therefore, we aimed to ascertain the Vitamin D status in pediatric and adolescent CF patients and its association with pulmonary exacerbations.
A retrospective study was conducted at The Aga Khan University Hospital from 2015 to 2018. Patients of CF with sweat chloride value >60 mmol/l and who had at least one measurement of 25 hydroxy Vitamin D (25 OHD) were included in the study. Annual serum Vitamin D levels were documented for enrolled patients and their past 1-year data were analyzed for pulmonary exacerbations, average length of stay, and tracheal/airway colonization with organisms.
69 patients were included in the study. 28 patients (40.57%) were found to be Vitamin D deficient, 22 patients (31.88%) were Vitamin D insufficient and 19 patients (27.53%) were labeled as Vitamin D insufficient. The average number of exacerbations per year was significantly high in Vitamin D deficient group (3.71 ± 0.96) in comparison with insufficient (3.18 ± 1.09) and sufficient groups (2.26 ± 0.93) (P < 0.001).
Vitamin D deficiency is related to an increased number of annual pulmonary exacerbations and pseudomonas infections.
维生素D在预防炎症和感染方面的作用此前已在全球不同人群的不同病理情况下进行过研究。在我们所在的地区，血清维生素D水平与其对囊性纤维化（CF）人群肺部加重的影响之间的关系尚未得到充分研究。因此，我们旨在确定儿科和青少年CF患者的维生素D状态及其与肺部加重的关联。
2015年至2018年在阿迦汗大学医院进行了一项回顾性研究。纳入研究的CF患者的汗液氯化物值>60 mmol/l，且至少有一次25羟维生素D（25 OHD）测量值。记录入组患者的年度血清维生素D水平，并分析他们过去1年的肺部加重、平均住院时间和气管/气道微生物定植数据。
69名患者纳入研究。发现28名患者（40.57%）维生素D缺乏，22名患者（31.88%）维生素D不足，19名患者（27.53%）维生素D充足。与维生素D不足组（3.18±1.09）和充足组（2.26±0.93）相比，维生素D缺乏组每年的平均加重次数显著更高（3.71±0.96）（P<0.001）。
维生素D缺乏与每年肺部加重次数增加和铜绿假单胞菌感染有关。
