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[妊娠中期的弥散性血管内凝血障碍。妊娠16周病例报告及足月自然分娩]

[Disseminated intravascular coagulation disorder in the 2d trimester of pregnancy. Case report from the 16th week of pregnancy with spontaneous parturition at term].

作者信息

Prömpeler H J, Wilhelm C, Zahradnik H P, Hasler K, Hillemanns H G

机构信息

Universitäts-Frauenklinik Freiburg.

出版信息

Geburtshilfe Frauenheilkd. 1989 Jul;49(7):679-81. doi: 10.1055/s-2008-1026678.

Abstract

After exercising on a trampoline, a 29-year-old primigravidae in the 16th week of gestation was admitted to our hospital with the clinical signs of premature ablatio placentae and acute coagulation disturbances with disseminated intravascular coagulation and uncontrolled secondary hyperfibrinolysis. The coagulation disturbance was stabilized by conservative therapy (Substitution with fresh-frozen-plasma (ffp), whole blood and low-dose heparin treatment without having to terminate the pregnancy by evacuation of the uterus. An appropriate antifibrinolytic treatment was not performed in this case. The continuous controls of fibrinmonomeres and reptilase time indicate the possibility of a persisting latent coagulation disturbance after the acute phase. Thus, the necessity of a low-dose heparin therapy after an acute coagulation disturbance becomes evident.

摘要

一名29岁的初产妇,孕16周,在蹦床运动后因胎盘早剥、急性凝血功能障碍伴弥散性血管内凝血及继发性纤溶亢进失控的临床症状入住我院。通过保守治疗(输注新鲜冰冻血浆(FFP)、全血及小剂量肝素治疗)凝血功能障碍得到稳定,无需行刮宫术终止妊娠。该病例未进行适当的抗纤溶治疗。对纤维蛋白单体和爬虫酶时间的持续监测表明急性期后可能存在持续的潜在凝血功能障碍。因此,急性凝血功能障碍后小剂量肝素治疗的必要性显而易见。

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