Wichit Sineewanlaya, Ferraris Pauline, Choumet Valérie, Missé Dorothée
Laboratory of MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France.
Environment and Infectious Risks Unit, Pasteur Institute, Paris, France.
Curr Opin Virol. 2016 Dec;21:139-145. doi: 10.1016/j.coviro.2016.10.001. Epub 2016 Oct 19.
Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.
登革热、基孔肯雅热和寨卡病毒等虫媒病毒，由于全球化以及易感媒介在全球范围内的传播，成为了一个重大的公共卫生问题。节肢动物媒介产生的唾液因子能够通过增强或抑制病毒复制来调节人体细胞功能，进而改变局部和全身病毒感染的发生。在此，我们讨论蚊子唾液如何干扰人类的登革热病毒（DENV）感染。鉴定增强感染性的唾液因子将有助于生产基于媒介的疫苗和治疗药物，这些药物可通过靶向节肢动物唾液成分来干扰病毒传播。了解唾液蛋白在登革热病毒传播中的作用，不仅将为控制登革热提供工具，也将为控制由相同媒介传播的其他虫媒病毒疾病提供工具。
