Özdil Demiryürek Esra, Tekin Atilla, Çakmak Engin, Temizkan Osman, Karamustafalıoğlu Oğuz, Gökova Sibel, Demiryürek Enes
Psychiatry Department, Sakarya University, Sakarya Training and Research Hospital, Turkey.
Psychiatry Department, Bolu Mental and Psychiatric Disease Hospital, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2016 Dec;207:5-10. doi: 10.1016/j.ejogrb.2016.09.002. Epub 2016 Oct 6.
The aim of this study was to investigate the relationship between anger, impulsiveness, and biochemical parameters (testosterone, insulin, insulin resistance) in women with polycystic ovary syndrome.
We recruited 84 women diagnosed with polycystic ovary syndrome according to the Rotterdam diagnostic criteria. Psychiatric interviews were performed using the Structured Clinical Interview for DSM-IV Axis I Disorders. The Barratt Impulsiveness Scale and the State Trait Anger Expression Inventory were also administered to each participant. Lastly, the women's biochemical parameters, which included total testosterone, free androgen index, dehydroepiandrosterone sulfate, insulin and insulin resistance, thyroid functions, and prolactin, were measured.
A statistically significant correlation was found between participants' increasing total testosterone levels and total impulsiveness scores, and their increasing free androgen index levels and motor and non-planning-related impulsiveness (r=0.24, p=0.027; r=0.27, p=0.015; and r=0.26, p=0.017, respectively). High insulin and insulin resistance levels were associated with high non-planning-related impulsiveness scores (r=0.26, p=0.018; and r=0.26, p=0.019). Lastly, high trait anger and anger expression scores were related to high total testosterone and insulin and insulin resistance levels.
Androgens and glucose dysregulation seemingly affect anger expression as well as the attentional, motor, and non-planning-related impulsiveness of women with polycystic ovary syndrome.
本研究旨在探讨多囊卵巢综合征女性的愤怒、冲动与生化参数（睾酮、胰岛素、胰岛素抵抗）之间的关系。
我们根据鹿特丹诊断标准招募了84名被诊断为多囊卵巢综合征的女性。使用《精神疾病诊断与统计手册》第四版轴I障碍的结构化临床访谈进行精神科访谈。还对每位参与者进行了巴拉特冲动量表和状态特质愤怒表达量表的测试。最后，测量了这些女性的生化参数，包括总睾酮、游离雄激素指数、硫酸脱氢表雄酮、胰岛素和胰岛素抵抗、甲状腺功能以及催乳素。
参与者总睾酮水平升高与总冲动得分之间，以及游离雄激素指数水平升高与运动及非计划相关冲动之间存在统计学显著相关性（分别为r = 0.24，p = 0.027；r = 0.27，p = 0.015；r = 0.26，p = 0.017）。高胰岛素和胰岛素抵抗水平与高非计划相关冲动得分相关（r = 0.26，p = 0.018；r = 0.26，p = 0.019）。最后，高特质愤怒和愤怒表达得分与高总睾酮、胰岛素和胰岛素抵抗水平相关。
雄激素和葡萄糖调节异常似乎会影响多囊卵巢综合征女性的愤怒表达以及注意力、运动和非计划相关的冲动。
