Sayed Fatma G., Hamza Amany I., Galal Lamia A., Sayed Douaa M., Gaber Mona
Department of Parasitology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71515, Egypt
Ann Parasitol. 2016 Oct 1;62(3):221-32. doi: 10.17420/ap6203.56.
Cryptosporidium parvum is a coccidian parasite which causes gastrointestinal disease in humans and a variety of other mammalian species. Several studies have reported different degrees of pathogenicity and virulence among Cryptosporidium species and isolates of the same species as well as evidence of variation in host susceptibility to infection. The study aimed to investigate infectivity and virulence of two Cryptosporidium parvum “Iowa isolate” (CpI) and a “local water isolate” (CpW). Thirty-three Swiss albino mice have been divided into three groups: Negative control Group (C), the CpI group infected with “Iowa isolate “and the CpW group infected with C. parvum oocysts isolated from a local water supply. Infectivity and virulence have been measured by evaluating clinical, parasitological and histological aspects of infection. Significant differences were detected regarding oocysts shedding rate, clinical outcomes, and the histopathological picture of the intestine, lung, and brain. It was concluded that the local water isolate is significantly more virulent than the exported one.
微小隐孢子虫是一种球虫寄生虫，可导致人类和多种其他哺乳动物患上胃肠道疾病。多项研究报告了隐孢子虫不同物种以及同一物种的不同分离株之间存在不同程度的致病性和毒力，同时也有证据表明宿主对感染的易感性存在差异。该研究旨在调查两种微小隐孢子虫“爱荷华分离株”（CpI）和一种“本地水源分离株”（CpW）的感染性和毒力。33只瑞士白化小鼠被分为三组：阴性对照组（C）、感染“爱荷华分离株”的CpI组以及感染从本地水源分离出的微小隐孢子虫卵囊的CpW组。通过评估感染的临床、寄生虫学和组织学方面来测量感染性和毒力。在卵囊排泄率、临床结果以及肠道、肺和脑的组织病理学图像方面检测到了显著差异。得出的结论是，本地水源分离株的毒力明显高于进口分离株。
