Zhu Guang-Hui, Mei Hai-Bo, He Rong-Guo, Liu Yao-Xi, Liu Kun, Tang Jin, Wu Jiang-Yan
Department of Orthopedics, Hunan Children's Hospital, 86 Ziyuan road, Changsha, Hunan, People's Republic of China.
BMC Musculoskelet Disord. 2016 Oct 22;17(1):443. doi: 10.1186/s12891-016-1295-1.
The purpose of this study was to investigate the initial union rate, refracture rate and residual deformities of congenital pseudarthrosis of the tibia (CPT), using combined surgery including pseudarthrosis resection, intramedullary rodding, autogenous iliac bone grafting and Ilizarov's fixator, with a mean 5.2 years follow-up.
We retrospectively reviewed the records and diagrams of patients with Crawford type IV congenital pseudarthrosis of the tibia between February 2007 and March 2010. Patients managed by pseudarthrosis resection, intramedullary rod of the tibia, wrapping autogenous iliac bone grafting and Ilizarov's fixator were enrolled. We evaluated the bone union rate, tibial alignment, limb length discrepancy (LLD), valgus deformity of the ankle and the frequencies of refracture during period of follow-up.
There were 56 cases enrolled in the study, with a mean follow-up 5.2 years (range, 3 to 6.7 years). The mean age of the patients at surgery was 3.5 years (range, 1.5 to 12.4 years). Fifty (89.2 %) of the 56 patients had primary bone union at site of pseudarthrosis, while 5 obtained union after second surgery and 1 failed. The average time spent to obtain pseudarthrosis initial union was 4.5 months (range, 3.0 to 10.0 months) and mean duration of Ilizarov treatment was 4.7 months (range, 3.2 to 10.4 months). Eleven (19.6 %) patients had proximal tibial valgus with a mean angle of 9.5° (range, 5 to 24°), while 10 (17.9 %) patients had ankle valgus deformities with a mean of 12.3° (range, 6 to 21°). Sixteen (28.6 %) patients had an average 2.2 cm LLD (range, 1.5-4.2 cm). Of the 50 cases who obtained initial bone union of pseudarthrosis, 13 (26.0 %) had refracture which need cast immobilization or secondary surgery.
This combined surgery obtained initial union rate of 89.2 % at primary surgery while the refracture rate is 26.0 %. However, residual deformities such as proximal tibial valgus, LLD and ankle valgus were also existed which should be pay more attention to and dealt with.
This study was registered in ClinicalTrials.gov under the name "The Effect of Combined Surgery in Management of Congenital Pseudarthrosis of Tibia" ( NCT02640040 ), which was released on August 31, 2015.
本研究旨在探讨采用包括假关节切除、髓内棒植入、自体髂骨移植和伊里扎洛夫固定器在内的联合手术治疗先天性胫骨假关节(CPT)的初期愈合率、再骨折率和残留畸形情况,并进行平均5.2年的随访。
我们回顾性分析了2007年2月至2010年3月间Crawford IV型先天性胫骨假关节患者的病历和影像学资料。纳入接受假关节切除、胫骨髓内棒植入、自体髂骨包裹移植及伊里扎洛夫固定器治疗的患者。我们评估了随访期间的骨愈合率、胫骨对线情况、肢体长度差异(LLD)、踝关节外翻畸形以及再骨折频率。
本研究共纳入56例患者,平均随访5.2年(范围3至6.7年)。患者手术时的平均年龄为3.5岁(范围1.5至12.4岁)。56例患者中,50例(89.2%)在假关节部位实现了一期骨愈合,5例在二次手术后实现愈合,1例未愈合。假关节实现初期愈合的平均时间为4.5个月(范围3.0至10.0个月),伊里扎洛夫治疗的平均持续时间为4.7个月(范围3.2至10.4个月)。11例(19.6%)患者出现胫骨近端外翻,平均角度为9.5°(范围5至24°),10例(17.9%)患者出现踝关节外翻畸形,平均角度为12.3°(范围6至21°)。16例(28.6%)患者平均存在2.2 cm的肢体长度差异(范围1.5 - 4.2 cm)。在50例实现假关节初期骨愈合的患者中,13例(26.0%)发生再骨折,需要石膏固定或二次手术。
这种联合手术在初次手术时的初期愈合率为89.2%,而再骨折率为26.0%。然而,仍存在诸如胫骨近端外翻、肢体长度差异和踝关节外翻等残留畸形,应予以更多关注并进行处理。
本研究在ClinicalTrials.gov上注册,名称为“联合手术治疗先天性胫骨假关节的效果”(NCT02640040),于2015年8月31日发布。