从床边到实验室再回到床边的研究：雌激素受体β配体作为多发性硬化症的候选神经保护治疗药物
Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis.
作者信息
Itoh Noriko, Kim Roy, Peng Mavis, DiFilippo Emma, Johnsonbaugh Hadley, MacKenzie-Graham Allan, Voskuhl Rhonda R
机构信息
Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, USA.
Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, USA.
出版信息
J Neuroimmunol. 2017 Mar 15;304:63-71. doi: 10.1016/j.jneuroim.2016.09.017. Epub 2016 Oct 3.
Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a "next generation estriol" treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted.
多发性硬化症（MS）病程中怀孕的保护作用促使人们对妊娠雌激素雌三醇进行MS临床试验。由于雌三醇与雌激素受体（ER）β结合，ERβ配体可能代表一种“下一代雌三醇”疗法。在此，ERβ配体治疗对不同性别和遗传背景的实验性自身免疫性脑脊髓炎（EAE）均具有保护作用。在脊髓中显示出神经保护作用，可保留髓鞘和轴突；在大脑中也有神经保护作用，可保留神经元和突触。纵向体内磁共振成像（MRI）显示，EAE期间大脑皮质灰质和小脑的脑萎缩减少。因此，有必要研究ERβ配体作为MS的神经保护疗法。
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