怀孕、产后及生育状况：大脑健康与疾病中的复原力和脆弱性
Pregnancy, postpartum and parity: Resilience and vulnerability in brain health and disease.
作者信息
Deems Nicholas P, Leuner Benedetta
机构信息
The Ohio State University, Department of Psychology, Columbus, OH, USA.
The Ohio State University, Department of Psychology, Columbus, OH, USA.
出版信息
Front Neuroendocrinol. 2020 Apr;57:100820. doi: 10.1016/j.yfrne.2020.100820. Epub 2020 Jan 24.
Abstract
Risk and resilience in brain health and disease can be influenced by a variety of factors. While there is a growing appreciation to consider sex as one of these factors, far less attention has been paid to sex-specific variables that may differentially impact females such as pregnancy and reproductive history. In this review, we focus on nervous system disorders which show a female bias and for which there is data from basic research and clinical studies pointing to modification in disease risk and progression during pregnancy, postpartum and/or as a result of parity: multiple sclerosis (MS), depression, stroke, and Alzheimer's disease (AD). In doing so, we join others (Shors, 2016; Galea et al., 2018a) in aiming to illustrate the importance of looking beyond sex in neuroscience research.
摘要
大脑健康与疾病中的风险和恢复力会受到多种因素的影响。虽然人们越来越认识到应将性别视为其中一个因素，但对于可能对女性产生不同影响的特定性别变量，如怀孕和生育史，却很少有人关注。在本综述中，我们重点关注那些在女性中更为常见的神经系统疾病，并且有基础研究和临床研究数据表明，在怀孕、产后和/或由于生育次数而导致疾病风险和病程发生改变的疾病：多发性硬化症（MS）、抑郁症、中风和阿尔茨海默病（AD）。这样做时，我们与其他人（肖尔斯，2016年；加利亚等人，2018年a）一道，旨在阐明在神经科学研究中超越性别看待问题的重要性。
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