Mählck C G, Bäckström T, Kjellgren O
Department of Obstetrics and Gynecology, University of Umeå, Sweden.
Gynecol Obstet Invest. 1989;28(1):41-6. doi: 10.1159/000293502.
The prognostic value of progesterone (P), androstenedione (A), Estradiol, Testosterone, 20 alpha-hydroxy-progesterone, sex hormone binding globulin, and albumin (Alb) was investigated in 51 women with ovarian carcinoma. All patients had observation periods greater than 5 years. The plasma concentrations of P, A, and Alb and the P/Alb and A/Alb ratios showed a significant correlation with the observation time of the patients. P, P/Alb, Alb, and A/Alb separately or in combination showed the highest prognostic specificity and sensitivity. The patients with a plasma concentration above an optimal limit or above mean + 2 SD of a control group of 20 postmenopausal women were grouped together. The groups with P/Alb, A, A/Alb, and Alb above the limit showed an equal survival rate as patients in FIGO stage IV. Patients with a high A/Alb ratio and a high testosterone concentration showed an even poorer prognosis than FIGO stage IV patients. Among the patients in stage IV the A/Alb ratio and sex hormone binding globulin gave additional prognostic information on the stage. The steroid concentration is not only related to tumor volume, as shown earlier, but also reflects the prognosis of the disease.
在51例卵巢癌女性患者中研究了孕酮（P）、雄烯二酮（A）、雌二醇、睾酮、20α-羟基孕酮、性激素结合球蛋白和白蛋白（Alb）的预后价值。所有患者的观察期均超过5年。P、A和Alb的血浆浓度以及P/Alb和A/Alb比值与患者的观察时间呈显著相关。P、P/Alb、Alb和A/Alb单独或联合使用时显示出最高的预后特异性和敏感性。血浆浓度高于20名绝经后女性对照组的最佳限值或高于均值+2标准差的患者被归为一组。P/Alb、A、A/Alb和Alb高于限值的组与国际妇产科联盟（FIGO）IV期患者的生存率相同。A/Alb比值高且睾酮浓度高的患者预后甚至比FIGO IV期患者更差。在IV期患者中，A/Alb比值和性激素结合球蛋白提供了关于该分期的额外预后信息。如先前所示，类固醇浓度不仅与肿瘤体积有关，还反映了疾病的预后。
