O'Brien M E, Dowsett M, Fryatt I, Wiltshaw E
Department of Biochemistry, Royal Marsden Hospital, London, U.K.
Eur J Cancer. 1994;30A(4):442-5. doi: 10.1016/0959-8049(94)90414-6.
Raised levels of steroid hormones are not expected in postmenopausal women. Therefore, if detected in postmenopausal women with ovarian cancer, they must be assumed to be related to the presence of the tumour and, therefore, may be of use as tumour markers. Serum levels of CA125, progesterone, 17-hydroxyprogesterone, sex hormone binding globulin and oestradiol were measured in 44 postmenopausal women with ovarian cancer, postsurgery and prior to chemotherapy. The relationship between the four hormone levels, CA125, patient age, stage, residual disease after surgery and differentiation were tested using the Spearman and Kendall rank coefficients. A significant inverse association was found between CA125 and progesterone levels, and CA125 and 17-hydroxyprogesterone. A positive association between 17-hydroxyprogesterone and progesterone was also found, and positive correlations between stage and CA125, and residual disease and CA125 were confirmed.
绝经后女性的类固醇激素水平预计不会升高。因此，如果在患有卵巢癌的绝经后女性中检测到这些激素，必须假定它们与肿瘤的存在有关，因此可能用作肿瘤标志物。对44名患有卵巢癌的绝经后女性在手术后和化疗前测定了血清CA125、孕酮、17-羟孕酮、性激素结合球蛋白和雌二醇水平。使用Spearman和Kendall秩系数检验了四种激素水平、CA125、患者年龄、分期、手术后残留疾病和分化之间的关系。发现CA125与孕酮水平、CA125与17-羟孕酮之间存在显著负相关。还发现17-羟孕酮与孕酮之间存在正相关，并且证实分期与CA125、残留疾病与CA125之间存在正相关。
