用于切伦科夫发光成像的镭、铅和铽的α衰变链产生的切伦科夫光。
Cherenkov light production from the α-emitting decay chains of Ra, Pb, and Tb for Cherenkov Luminescence Imaging.
作者信息
Wood V, Ackerman N L
机构信息
Department of Physics and Astronomy, Agnes Scott College, 141 E College Ave, Decatur, GA, 30030 United States.
Department of Physics and Astronomy, Agnes Scott College, 141 E College Ave, Decatur, GA, 30030 United States.
出版信息
Appl Radiat Isot. 2016 Dec;118:354-360. doi: 10.1016/j.apradiso.2016.10.009. Epub 2016 Oct 12.
Cherenkov Luminescence Imaging (CLI) is a new method to image radioactive therapeutic and diagnostic agents, primarily in preclinical studies. This study used Geant4 and Python to generate the predicted Cherenkov light production as a function of time for a set of isotopic chains of interest for targeted alpha therapy: Ra, Pb, and Tb. All are shown to produce substantial Cherenkov light, though time delays between initial decays and the production of Cherenkov light requires caution in interpreting CLI.
切伦科夫发光成像（CLI）是一种用于对放射性治疗和诊断剂进行成像的新方法，主要应用于临床前研究。本研究使用Geant4和Python来生成一系列针对靶向α治疗的感兴趣同位素链（镭、铅和铽）的切伦科夫光产生量随时间变化的预测值。结果表明，所有这些同位素都会产生大量的切伦科夫光，不过在解释CLI结果时，需要注意初始衰变与切伦科夫光产生之间的时间延迟。
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