Nandi Arindam, Barter Devra M, Prinja Shankar, John T Jacob
Center for Disease Dynamics, Economics and Policy, Washington, USA; *School of Public Health, Chandigarh, India; and #Retired Professor of Clinical Virology, Christian Medical College, Vellore, TN, India. Correspondence to: Dr Arindam Nandi, The Center for Disease Dynamics, Economics and Policy, Washington, USA.
Indian Pediatr. 2016 Aug 7;53 Suppl 1:S7-S13.
In March 2014, India, the country with historically the highest burden of polio, was declared polio free, with no reported cases since January 2011. We estimate the health and economic benefits of polio elimination in India with the oral polio vaccine (OPV) during 1982-2012.
Based on a pre-vaccine incidence rate, we estimate the counterfactual burden of polio in the hypothetical absence of the national polio elimination program in India. We attribute differences in outcomes between the actual (adjusted for under-reporting) and hypothetical counterfactual scenarios in our model to the national polio program. We measure health benefits as averted polio incidence, deaths, and disability adjusted life years (DALYs). We consider two methods to measure economic benefits: the value of statistical life approach, and equating one DALY to the Gross National Income (GNI) per capita.
We estimate that the National Program against Polio averted 3.94 million (95% confidence interval [CI]: 3.89-3.99 million) paralytic polio cases, 393,918 polio deaths (95% CI: 388,897- 398,939), and 1.48 billion DALYs (95% CI: 1.46-1.50 billion). We also estimate that the program contributed to a $1.71 trillion (INR 76.91 trillion) gain (95% CI: $1.69-$1.73 trillion [INR 75.93-77.89 trillion]) in economic productivity between 1982 and 2012 in our base case analysis. Using the GNI and DALY method, the economic gain from the program is estimated to be $1.11 trillion (INR 50.13 trillion) (95% CI: $1.10-$1.13 trillion [INR 49.50-50.76 trillion]) over the same period.
India accrued large health and economic benefits from investing in polio elimination efforts. Other programs to control/eliminate more vaccine-preventable diseases are likely to contribute to large health and economic benefits in India.
2014年3月,印度这个历史上脊髓灰质炎负担最重的国家宣布已消灭脊髓灰质炎,自2011年1月以来无病例报告。我们估计了1982 - 2012年期间印度通过口服脊髓灰质炎疫苗(OPV)消除脊髓灰质炎所带来的健康和经济效益。
基于疫苗接种前的发病率,我们估计了在假设印度没有国家脊髓灰质炎消除计划的情况下脊髓灰质炎的反事实负担。我们将模型中实际情况(针对漏报进行了调整)与假设的反事实情况之间的结果差异归因于国家脊髓灰质炎计划。我们将避免的脊髓灰质炎发病率、死亡人数和伤残调整生命年(DALYs)作为健康效益进行衡量。我们考虑两种衡量经济效益的方法:统计生命价值法,以及将一个DALY等同于人均国民总收入(GNI)。
我们估计国家脊髓灰质炎防治计划避免了394万例(95%置信区间[CI]:389 - 399万例)麻痹性脊髓灰质炎病例、393,918例脊髓灰质炎死亡(95% CI:388,897 - 398,939例)以及14.8亿DALYs(95% CI:14.6 - 15.0亿)。在我们的基础案例分析中,我们还估计该计划在1982年至2012年期间为经济生产力带来了1.71万亿美元(76.91万亿印度卢比)的收益(95% CI:1.69 - 1.73万亿美元[75.93 - 77.89万亿印度卢比])。使用GNI和DALY方法,估计同期该计划带来的经济收益为1.11万亿美元(50.13万亿印度卢比)(95% CI:1.10 - 1.13万亿美元[49.50 - 50.76万亿印度卢比])。
印度在脊髓灰质炎消除工作上的投入带来了巨大的健康和经济效益。其他控制/消除更多疫苗可预防疾病的计划可能会给印度带来巨大的健康和经济效益。