Rådberg G, Samsioe G, Svanvik J
Department of Surgery, Sahlgrens' Hospital, Gothenburg, Sweden.
Horm Metab Res. 1989 May;21(5):240-4. doi: 10.1055/s-2007-1009203.
Variations in the occurrence of prostaglandin precursor fatty acids might be of importance for the pathogenesis of gallstones. Pregnancy and use of contraceptive steroids increase the risk of gallstones. The present study reports the relative fatty acid composition in serum and biliary phospholipids studied by gas-liquid chromatography in four groups of female cats, which were on a standard diet: 1) oophorectomized animals, 2) animals on contraceptive steroids, 3) pregnant animals and 4) control animals. It was consistently found that the portions of palmitic and linoleic acid were higher and stearic and arachidonic acid were lower in biliary than in serum lecithin. In biliary lysolecithin, sphingomyelin and cephaline there were only small portions of linoleic and negligible amounts of arachidonic acid. Oophorectomy, contraceptive steroids or pregnancy did not induce any gross changes in the fatty acid pattern of lecithin in serum or bile. In animals treated with contraceptive steroids a reduced portion of linoleic acid was seen in the bile lecithin, and in pregnant animals there was a reduction of omega 3 and omega 6 fatty acids in biliary lecithin.
前列腺素前体脂肪酸出现情况的变化可能对胆结石的发病机制具有重要意义。怀孕和使用避孕类固醇会增加患胆结石的风险。本研究报告了通过气液色谱法研究的四组雌性猫血清和胆汁磷脂中的相对脂肪酸组成，这些猫采用标准饮食：1）卵巢切除的动物，2）使用避孕类固醇的动物，3）怀孕的动物和4）对照动物。一致发现，胆汁中棕榈酸和亚油酸的比例高于血清卵磷脂，而硬脂酸和花生四烯酸的比例低于血清卵磷脂。在胆汁溶血卵磷脂、鞘磷脂和脑磷脂中，亚油酸的比例很小，花生四烯酸的含量可忽略不计。卵巢切除、避孕类固醇或怀孕并未引起血清或胆汁中卵磷脂脂肪酸模式的任何明显变化。在用避孕类固醇治疗的动物中，胆汁卵磷脂中亚油酸的比例降低，而在怀孕动物中，胆汁卵磷脂中ω-3和ω-6脂肪酸减少。
