心率变异性：部署后创伤后应激障碍症状的部署前预测指标。

Heart rate variability: Pre-deployment predictor of post-deployment PTSD symptoms.

作者信息

Pyne Jeffrey M, Constans Joseph I, Wiederhold Mark D, Gibson Douglas P, Kimbrell Timothy, Kramer Teresa L, Pitcock Jeffery A, Han Xiaotong, Williams D Keith, Chartrand Don, Gevirtz Richard N, Spira James, Wiederhold Brenda K, McCraty Rollin, McCune Thomas R

机构信息

Center for Mental Health Outcomes Research, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; South Central Mental Illness Education and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; Division of Health Services Research, Department of Psychiatry, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States.

South Central Mental Illness Education and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; Southeastern Louisiana Veterans Health Care System (629/11F), PO Box 61011, New Orleans, LA 70161, United States, United States; Tulane University, New Orleans, LA, United States.

出版信息

Biol Psychol. 2016 Dec;121(Pt A):91-98. doi: 10.1016/j.biopsycho.2016.10.008. Epub 2016 Oct 20.

DOI:10.1016/j.biopsycho.2016.10.008

PMID:27773678

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5335901/

Abstract

Heart rate variability is a physiological measure associated with autonomic nervous system activity. This study hypothesized that lower pre-deployment HRV would be associated with higher post-deployment post-traumatic stress disorder (PTSD) symptoms. Three-hundred-forty-three Army National Guard soldiers enrolled in the Warriors Achieving Resilience (WAR) study were analyzed. The primary outcome was PTSD symptom severity using the PTSD Checklist - Military version (PCL) measured at baseline, 3- and 12-month post-deployment. Heart rate variability predictor variables included: high frequency power (HF) and standard deviation of the normal cardiac inter-beat interval (SDNN). Generalized linear mixed models revealed that the pre-deployment PCL*ln(HF) interaction term was significant (p<0.0001). Pre-deployment SDNN was not a significant predictor of post-deployment PCL. Covariates included age, pre-deployment PCL, race/ethnicity, marital status, tobacco use, childhood abuse, pre-deployment traumatic brain injury, and previous combat zone deployment. Pre-deployment heart rate variability predicts post-deployment PTSD symptoms in the context of higher pre-deployment PCL scores.

摘要

心率变异性是一种与自主神经系统活动相关的生理指标。本研究假设，部署前较低的心率变异性与部署后较高的创伤后应激障碍（PTSD）症状相关。对参加“勇士实现复原力（WAR）”研究的343名陆军国民警卫队士兵进行了分析。主要结局是使用创伤后应激障碍检查表-军事版（PCL）在部署前、部署后3个月和12个月测量的创伤后应激障碍症状严重程度。心率变异性预测变量包括：高频功率（HF）和正常心搏间期的标准差（SDNN）。广义线性混合模型显示，部署前PCL*ln（HF）交互项具有显著性（p<0.0001）。部署前的SDNN不是部署后PCL的显著预测因子。协变量包括年龄、部署前PCL、种族/民族、婚姻状况、烟草使用、童年虐待、部署前创伤性脑损伤和先前的战区部署。在部署前PCL得分较高的情况下，部署前心率变异性可预测部署后创伤后应激障碍症状。