无乳链球菌血清型VI的基因组及比较分析
The genome of serotype VI Streptococcus agalactiae serotype VI and comparative analysis.
作者信息
He En-Ming, Chen Cheng-Wen, Guo Yong, Hsu Mei-Hua, Zhang Liang, Chen Hsiu-Ling, Zhao Guo-Ping, Chiu Cheng-Hsun, Zhou Yan
机构信息
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, People's Republic of China.
出版信息
Gene. 2017 Jan 15;597:59-65. doi: 10.1016/j.gene.2016.10.030. Epub 2016 Oct 20.
Streptococcus agalactiae (GBS) causes serious infections in humans and other species. A total of 25 complete GBS genomes, including the first sequenced serotype VI genome (GBS-M002), were compared in this study. The power law model suggested that the pan-genome of GBS is open, with approximately 1300 genes in the core genome of GBS, accounting for approximately 60% of the average genome content. GBS-M002 has 73 specific genes and is one of the five strains containing >60 specific genes. Based on COG (Cluster of Orthologous Groups of proteins) functional classification, 24% of the genes related to defense mechanisms are specific among the strains. A phylogenetic tree shows that GBS-M002 is closely related to certain strains of serotypes III and V from humans and to isolates of unknown serotype from dog and bovine hosts, suggesting the universal infection potential of GBS from humans to other mammal and fish hosts.
无乳链球菌（GBS）可引发人类及其他物种的严重感染。本研究共比较了25个完整的GBS基因组，包括首个测序的VI型基因组（GBS-M002）。幂律模型表明GBS的泛基因组是开放的，GBS核心基因组中约有1300个基因，约占平均基因组含量的60%。GBS-M002有73个特异基因，是含有>60个特异基因的五个菌株之一。基于蛋白质直系同源簇（COG）功能分类，24%与防御机制相关的基因在菌株间具有特异性。系统发育树显示GBS-M002与来自人类的某些III型和V型菌株以及来自犬类和牛类宿主的未知血清型分离株密切相关，这表明GBS具有从人类传播到其他哺乳动物和鱼类宿主的普遍感染潜力。
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