Benvenuti C, Gambaro V, Lodi F, Scaroni C, Bandi G, Valenti M
Medical Dept., Boots-Formenti, Milan, Italy.
Int J Clin Pharmacol Ther Toxicol. 1989 Jul;27(7):334-7.
The bioavailability of granules and tablet flurbiprofen in 100 mg single dose was crossover compared in 6 healthy volunteers (mean aged 26.8 years). The granules showed an earlier peaktime and a lower maximum concentration than the tablet. Area under the curve and half-time in terminal phase were similar, with the granule relative bioavailability of 0.98.
在6名健康志愿者（平均年龄26.8岁）中对100毫克单剂量的氟比洛芬颗粒和片剂的生物利用度进行了交叉比较。与片剂相比，颗粒剂的达峰时间更早，最大浓度更低。曲线下面积和终末相半衰期相似，颗粒剂的相对生物利用度为0.98。
