Cox S R, Forbes K K
Pharmacokinetic/Pharmacodynamic Research Unit, Upjohn Company, Kalamazoo, Michigan 49001.
Pharmacotherapy. 1987;7(6):211-5. doi: 10.1002/j.1875-9114.1987.tb03527.x.
The extent of flurbiprofen's excretion into mature (postcolostrum) breast milk was evaluated in 10 healthy, nursing mothers after administration of a single 100-mg tablet. Samples of milk and blood were subsequently obtained over a 48-hour period and assayed for flurbiprofen by high-performance liquid chromatography. The average peak plasma flurbiprofen concentration, 15 micrograms/ml, occurred at 1.5 hours, and the harmonic mean half-life of the drug was 5.8 hours. The average peak milk concentration of flurbiprofen was 0.09 microgram/ml, and the maximum recovery of the dose in breast milk was only 0.07%.
在10名健康的哺乳期母亲服用一片100毫克的氟比洛芬片剂后，评估了氟比洛芬排泄到成熟（初乳期后）母乳中的程度。随后在48小时内采集母乳和血液样本，并用高效液相色谱法检测氟比洛芬。血浆中氟比洛芬的平均峰值浓度为15微克/毫升，出现在服药后1.5小时，该药的调和平均半衰期为5.8小时。母乳中氟比洛芬的平均峰值浓度为0.09微克/毫升，母乳中药物剂量的最大回收率仅为0.07%。
