Department of Neurology, University of Münster, Münster.
Department of Neurology, University Hospital Würzburg, Würzburg.
Ann Neurol. 2016 Dec;80(6):946-951. doi: 10.1002/ana.24807. Epub 2016 Nov 14.
Animal models have implicated an integral role for coagulation factors in neuroinflammatory diseases such as multiple sclerosis (MS) beyond their role in hemostasis. However, their relevance in humans requires further elucidation. This study aimed to determine whether levels of coagulation factors differ between patients with neuroimmunological disorders and respective controls. Individuals suffering from relapsing-remitting and secondary progressive MS had significantly higher prothrombin and factor X levels than healthy donors, whereas levels were unchanged in primary progressive MS and neuromyelitis optica patients. Our study demonstrates that coagulation factors may be key mediators in neuroinflammation and may therefore provide future targets for therapeutic strategies. Ann Neurol 2016;80:946-951.
动物模型表明，凝血因子在神经炎症性疾病（如多发性硬化症）中的作用不仅仅局限于止血，而是具有重要作用。然而，它们在人类中的相关性仍需要进一步阐明。本研究旨在确定神经免疫性疾病患者与相应对照组之间凝血因子水平是否存在差异。与健康供体相比，复发缓解型和继发进展型多发性硬化症患者的凝血酶原和因子 X 水平显著升高，而原发性进展型多发性硬化症和视神经脊髓炎患者的水平则保持不变。本研究表明，凝血因子可能是神经炎症的关键介质，因此可能为治疗策略提供新的靶点。《神经病学年鉴》2016 年；80：946-951.
