Nuvoli Susanna, Spanu Angela, Madeddu Giuseppe
Unit of Nuclear Medicine, Department of Clinical and Experimental Medicine, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.
Curr Alzheimer Res. 2017;14(2):143-153. doi: 10.2174/1567205013666161019144406.
As well known, the increase in life expectancy and the better physical condition of people in western countries will lead in the next 20 years to a dramatic development of neurodegenerative diseases, especially of dementia that could be considered one of the most important problems in clinical, social and economic fields for the future. Therefore, the differential diagnosis of the various types of dementia is a critical step for patients, clinicians and researchers since an accurate "in vivo" diagnosis can lead to a better patients management. Neuroimaging techniques and in particular the most diffuse and affordable single photon emission computed tomography (SPECT) have provided useful information about dementia disorders and these methods, on the basis of the recent advances, will have an increasingly important role in research and clinical practice. The purpose of this article is to analyze the different SPECT techniques now available which proved clinically useful in correctly formulating the differential diagnosis of dementia.
众所周知，西方国家人均预期寿命的延长和身体状况的改善，将在未来20年导致神经退行性疾病急剧增加，尤其是痴呆症，这可能被视为未来临床、社会和经济领域最重要的问题之一。因此，对各种类型痴呆症进行鉴别诊断，对患者、临床医生和研究人员来说都是关键步骤，因为准确的“活体”诊断有助于更好地管理患者。神经成像技术，尤其是最普及且经济实惠的单光子发射计算机断层扫描（SPECT），已经为痴呆症疾病提供了有用信息，基于最近的进展，这些方法在研究和临床实践中将发挥越来越重要的作用。本文旨在分析目前可用的不同SPECT技术，这些技术已被证明在正确进行痴呆症鉴别诊断方面具有临床实用性。
