Li Jie, Gao Yonghong, Ren Xiaomeng, Li Yanda, Wu Lijun, Yang Xinyu, Wang Jie, Shang Hongcai, Xiong Xingjiang, Xing Yanwei
Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.
The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
Curr Pharm Des. 2017;23(7):1060-1069. doi: 10.2174/1381612822666161021161850.
Autophagy, a highly conserved starvation response mechanism with both defensive and protective effects in eukaryotic cells, is a lysosome-mediated degradation process for non-essential or damaged cellular constituents. It plays an important role in the cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in cardiovascular diseases, cerebrovascular diseases, and neurodegenerative diseases, as well as tumours. Thus, modulating autophagy may provide potential therapeutic strategies. Recently, many active components of Chinese herbal medicines (CHM) have been found to modulate autophagy in myocardial cells, cerebral vascular cells, endothelial cells and tumour cells. This paper reviews the advances in studies on the active components of CHM that modulating autophagy in treating cardiovascular diseases and other chronic diseases over the past five years.
自噬是真核细胞中一种高度保守的饥饿反应机制，具有防御和保护作用，是一种由溶酶体介导的对非必需或受损细胞成分的降解过程。它在细胞存活、分化和发育以维持体内平衡方面发挥着重要作用。自噬与心血管疾病、脑血管疾病、神经退行性疾病以及肿瘤有关。因此，调节自噬可能提供潜在的治疗策略。近年来，已发现许多中药活性成分可调节心肌细胞、脑血管细胞、内皮细胞和肿瘤细胞中的自噬。本文综述了过去五年中药活性成分调节自噬治疗心血管疾病和其他慢性病的研究进展。
