He Ying, Bai Xiao-Jun, Li Fen-Xia, Fan Li-Hong, Ren Jie, Liang Qi, Li Hong-Bing, Bai Ling, Tian Hong-Yan, Fan Fen-Ling, Tian Gang, Ma Ai-Qun, Chen Jinghong
a Institute of Endemic Disease, Xi'an Jiao Tong University College of Medicine , Xi'an City , Shaanxi Province , China.
b Department of Cardiology , The First Affiliated Hospital of Xi'an Jiao Tong University , Shaanxi Province , China.
Biomarkers. 2017 May-Jun;22(3-4):291-295. doi: 10.1080/1354750X.2016.1252953. Epub 2016 Nov 9.
To investigate whether resistin is associated with early atherosclerosis in male smokers. The present study consecutively enrolled 50 male smokers. Their serum resistin contents were detected with enzyme linked immunosorbent assay (ELISA), and subclinical atherosclerosis indices, including carotid inner middle thickness (IMT) and arterial elasticity indices (C1 and C2), were measured. The association between serum resistin levels and IMT, C1 and C2 were respectively evaluated with the Pearson's correlation coefficient method. The results showed that the serum resistin level had a positive association with IMT (r = 0.307, p = .030), but were both inversely associated with C1 (r = -0.440, p = .001) and C2 (r = -0.381, p = .006). These associations remained significant even after adjustment for cardiovascular confounders. In conclusion, serum resistin concentration was independently associated with early atherosclerosis in male smokers.
