临床诱导急性心肌梗死中高敏心肌肌钙蛋白I和T以及肌钙蛋白T上游开放阅读框肽（TnTuORF）的释放动力学
Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction.
作者信息
Liebetrau Christoph, Gaede Luise, Wolter J Sebastian, Homann Julia, Meyer Alexander, Dörr Oliver, Nef Holger M, Troidl Christian, Hamm Christian W, Möllmann Helge, Richards A Mark, Pemberton Chris J
机构信息
a Department of Cardiology , Kerckhoff Heart and Thorax Center , Bad Nauheim , Germany.
b DZHK (German Center for Cardiovascular Research), partner site RheinMain , Frankfurt am Main , Germany.
出版信息
Biomarkers. 2017 May-Jun;22(3-4):304-310. doi: 10.1080/1354750X.2016.1252965. Epub 2016 Nov 22.
CONTEXT
Troponin T upstream open reading frame peptide (TnTuORF) may be useful as a novel biomarker in acute cardiac syndromes.
OBJECTIVE
The study examined the early release kinetics of TnTuORF.
MATERIALS AND METHODS
We analyzed the time course of the release of cardiac troponins I and T and TnTuORF in patients (n = 31) with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH).
RESULTS
Fifteen minutes after TASH, the levels of both troponins increased significantly (cTnT median: 18 ng/L versus 27 ng/L; cTnI median: 15 ng/L versus 25 ng/L). TnTuORF showed no variation.
DISCUSSION
We observed a significantly greater increase in cTnI compared with cTnT.
CONCLUSION
Our results demonstrate that troponin assays allow early detection of myocardial injury, whereas TnTuORF levels remain unchanged in this setting.
背景
肌钙蛋白T上游开放阅读框肽（TnTuORF）可能作为急性心脏综合征的一种新型生物标志物。
目的
本研究检测了TnTuORF的早期释放动力学。
材料与方法
我们分析了31例肥厚性梗阻性心肌病患者在接受经冠状动脉室间隔肥厚消融术（TASH）时心肌肌钙蛋白I和T以及TnTuORF的释放时间过程。
结果
TASH后15分钟，两种肌钙蛋白水平均显著升高（肌钙蛋白T中位数：18 ng/L对27 ng/L；肌钙蛋白I中位数：15 ng/L对25 ng/L）。TnTuORF无变化。
讨论
我们观察到肌钙蛋白I的升高显著大于肌钙蛋白T。
结论
我们的结果表明，肌钙蛋白检测可早期发现心肌损伤，而在此情况下TnTuORF水平保持不变。
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