DeBlasio D, McCormick B, Straus D, Smith M, Brustein S, Nisce L, Fuks Z
Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Int J Radiat Oncol Biol Phys. 1989 Oct;17(4):843-6. doi: 10.1016/0360-3016(89)90076-x.
A diagnosis of primary non-Hodgkin's lymphoma (NHL) confined to the breast or breast and ipsilateral lymph nodes was biopsy proven in 19 patients who presented to our institution between 1970 and 1984. Four patients were treated with a modified radical mastectomy, and one with chemotherapy only. The remaining 14 patients comprise the basis of this study. All patients were clinically staged. There were 12 patients with 1A-E disease and two with IIA-E disease. All patients were treated with breast radiation. The axillary nodes were included in seven of the patients and two, in addition, received "mantle" irradiation. The majority of the patients received between 3500-4400 cGy, but four received lower doses. One patient, with Stage IIA-E disease, received 6 months of systemic chemotherapy, followed by 3500 cGy to the breast and axilla. Three of the 14 patients relapsed within the treated area, with a local control rate of 78%. One was salvaged with a mastectomy and remains alive and well 15 years after diagnosis. Seven of the 14 patients relapsed distantly, including two with local failures, but only three have died of disease. An additional two patients have died of other causes without evidence of disease, for a survival of 66% at 48 months (Kaplan-Meier Calculations).
1970年至1984年间，有19名患者到我院就诊，经活检证实患有局限于乳腺或乳腺及同侧淋巴结的原发性非霍奇金淋巴瘤（NHL）。4例患者接受了改良根治性乳房切除术，1例仅接受化疗。其余14例患者构成了本研究的基础。所有患者均进行了临床分期。有12例患者为ⅠA-E期疾病，2例为ⅡA-E期疾病。所有患者均接受了乳腺放疗。7例患者的腋窝淋巴结接受了放疗，另外2例还接受了“斗篷式”照射。大多数患者接受的剂量在3500-4400 cGy之间，但有4例接受的剂量较低。1例ⅡA-E期疾病患者接受了6个月的全身化疗，随后对乳腺和腋窝给予3500 cGy的放疗。14例患者中有3例在治疗区域内复发，局部控制率为78%。1例通过乳房切除术挽救，诊断后15年仍存活且状况良好。14例患者中有7例远处复发，其中2例有局部失败，但只有3例死于该疾病。另外2例患者死于其他原因，无疾病证据，48个月时生存率为66%（Kaplan-Meier计算）。
