急性围产期哨兵事件、新生儿脑损伤模式以及接受新生儿缺氧缺血性脑病低温治疗试验的婴儿的结局
Acute Perinatal Sentinel Events, Neonatal Brain Injury Pattern, and Outcome of Infants Undergoing a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy.
作者信息
Shankaran Seetha, Laptook Abbot R, McDonald Scott A, Hintz Susan R, Barnes Patrick D, Das Abhik, Higgins Rosemary D
机构信息
Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
Department of Pediatrics, Women and Infant's Hospital, Brown University, Providence, RI.
出版信息
J Pediatr. 2017 Jan;180:275-278.e2. doi: 10.1016/j.jpeds.2016.09.026. Epub 2016 Oct 21.
Abstract
UNLABELLED
Infants with perinatal sentinel events in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Hypothermia for Encephalopathy Trial had more basal ganglia and thalamus lesions on brain magnetic resonance imaging but similar neurodevelopmental outcomes at 18 months of age than infants without perinatal sentinel events. Outcomes correlated with the neonatal magnetic resonance imaging findings.
TRIAL REGISTRATION
ClinicalTrials.gov: NCT00005772.
摘要
未标注
在尤妮斯·肯尼迪·施莱佛国家儿童健康与人类发展研究所新生儿研究网络的脑病低温治疗试验中，发生围产期哨兵事件的婴儿在脑磁共振成像上基底神经节和丘脑病变更多，但在18个月大时的神经发育结局与未发生围产期哨兵事件的婴儿相似。结局与新生儿磁共振成像结果相关。
试验注册
ClinicalTrials.gov：NCT00005772。
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本文引用的文献
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J Pediatr. 2015 Nov;167(5):987-93.e3. doi: 10.1016/j.jpeds.2015.08.013. Epub 2015 Sep 16.
2
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Pediatrics. 2014 Jun;133(6):1146-50. doi: 10.1542/peds.2014-0899.
3
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4
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5
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6
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7
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