• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

急性围产期哨兵事件、新生儿脑损伤模式以及接受新生儿缺氧缺血性脑病低温治疗试验的婴儿的结局

Acute Perinatal Sentinel Events, Neonatal Brain Injury Pattern, and Outcome of Infants Undergoing a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy.

作者信息

Shankaran Seetha, Laptook Abbot R, McDonald Scott A, Hintz Susan R, Barnes Patrick D, Das Abhik, Higgins Rosemary D

机构信息

Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.

Department of Pediatrics, Women and Infant's Hospital, Brown University, Providence, RI.

出版信息

J Pediatr. 2017 Jan;180:275-278.e2. doi: 10.1016/j.jpeds.2016.09.026. Epub 2016 Oct 21.

DOI:10.1016/j.jpeds.2016.09.026
PMID:27776752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5183477/
Abstract

UNLABELLED

Infants with perinatal sentinel events in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Hypothermia for Encephalopathy Trial had more basal ganglia and thalamus lesions on brain magnetic resonance imaging but similar neurodevelopmental outcomes at 18 months of age than infants without perinatal sentinel events. Outcomes correlated with the neonatal magnetic resonance imaging findings.

TRIAL REGISTRATION

ClinicalTrials.gov: NCT00005772.

摘要

未标注

在尤妮斯·肯尼迪·施莱佛国家儿童健康与人类发展研究所新生儿研究网络的脑病低温治疗试验中，发生围产期哨兵事件的婴儿在脑磁共振成像上基底神经节和丘脑病变更多，但在18个月大时的神经发育结局与未发生围产期哨兵事件的婴儿相似。结局与新生儿磁共振成像结果相关。

试验注册

ClinicalTrials.gov：NCT00005772。

相似文献

1
Acute Perinatal Sentinel Events, Neonatal Brain Injury Pattern, and Outcome of Infants Undergoing a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy.急性围产期哨兵事件、新生儿脑损伤模式以及接受新生儿缺氧缺血性脑病低温治疗试验的婴儿的结局
J Pediatr. 2017 Jan;180:275-278.e2. doi: 10.1016/j.jpeds.2016.09.026. Epub 2016 Oct 21.
2
Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic-Ischemic Encephalopathy in the Late Hypothermia Trial.常规磁共振成像作为预测新生儿缺氧缺血性脑病低温治疗后死亡或残疾的局限性：晚期低温治疗试验。
J Pediatr. 2021 Mar;230:106-111.e6. doi: 10.1016/j.jpeds.2020.11.015. Epub 2020 Nov 13.
3
Neonatal Magnetic Resonance Imaging Pattern of Brain Injury as a Biomarker of Childhood Outcomes following a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy.新生儿缺氧缺血性脑病亚低温治疗后，脑损伤的新生儿磁共振成像模式作为儿童期预后的生物标志物
J Pediatr. 2015 Nov;167(5):987-93.e3. doi: 10.1016/j.jpeds.2015.08.013. Epub 2015 Sep 16.
4
A comparison of criteria for defining metabolic acidemia in live-born neonates and its effect on predicting serious adverse neonatal outcomes.比较用于定义活产新生儿代谢性酸中毒的标准及其对预测严重不良新生儿结局的影响。
Am J Obstet Gynecol. 2023 Oct;229(4):439.e1-439.e11. doi: 10.1016/j.ajog.2023.03.031. Epub 2023 Mar 25.
5
Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III).亚低温治疗联合别嘌醇治疗新生儿缺氧缺血性脑损伤对神经认知结局的影响（ALBINO）：一项盲法随机安慰剂对照平行分组多中心优效性（III 期）临床试验方案。
BMC Pediatr. 2019 Jun 27;19(1):210. doi: 10.1186/s12887-019-1566-8.
6
The relationship between clinically identifiable intrapartum sentinel events and short-term outcome after therapeutic hypothermia.产时临床可识别的哨兵事件与治疗性低体温后短期结局的关系。
J Pediatr. 2011 Nov;159(5):726-30. doi: 10.1016/j.jpeds.2011.04.014. Epub 2011 May 19.
7
Cerebral injuries in neonatal encephalopathy treated with hypothermia: French LyTONEPAL cohort.新生儿脑病伴脑损伤行低温治疗的研究：法国 LyTONEPAL 队列研究
Pediatr Res. 2022 Sep;92(3):880-887. doi: 10.1038/s41390-021-01846-3. Epub 2021 Nov 20.
8
Perinatal events and early magnetic resonance imaging in therapeutic hypothermia.围产期事件与治疗性低体温的早期磁共振成像。
J Pediatr. 2011 Mar;158(3):360-5. doi: 10.1016/j.jpeds.2010.09.003. Epub 2010 Oct 20.
9
Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy.促红细胞生成素与低温治疗缺氧缺血性脑病
Pediatr Neurol. 2014 Nov;51(5):657-62. doi: 10.1016/j.pediatrneurol.2014.08.010. Epub 2014 Aug 27.
10
Serum Lactate, Brain Magnetic Resonance Imaging and Outcome of Neonatal Hypoxic Ischemic Encephalopathy after Therapeutic Hypothermia.血清乳酸、脑磁共振成像与治疗性低温后新生儿缺氧缺血性脑病的预后
Pediatr Neonatol. 2016 Feb;57(1):35-40. doi: 10.1016/j.pedneo.2015.04.008. Epub 2015 May 27.

引用本文的文献

1
Emerging modalities for neuroprognostication in neonatal encephalopathy: harnessing the potential of artificial intelligence.新生儿脑病神经预后评估的新兴模式：挖掘人工智能的潜力
Pediatr Res. 2025 Aug 19. doi: 10.1038/s41390-025-04336-y.
2
Translational Potential of Stem Cell-based Therapies in the Treatment of Neonatal Hypoxic-ischemic Brain Injury.基于干细胞的疗法在治疗新生儿缺氧缺血性脑损伤中的转化潜力
Stem Cell Rev Rep. 2025 Jun 5. doi: 10.1007/s12015-025-10905-9.
3
Shifting outlooks after neonatal encephalopathy in the era of therapeutic hypothermia.治疗性低温时代新生儿脑病后的预后变化
Pediatr Res. 2025 Jun 4. doi: 10.1038/s41390-025-04156-0.
4
Neonatal encephalopathy: a systematic review of reported treatment outcomes.新生儿脑病：已报道治疗结局的系统综述。
BMJ Paediatr Open. 2024 Sep 25;8(1):e002510. doi: 10.1136/bmjpo-2024-002510.
5
Hypothermia for Hypoxic-ischemic Encephalopathy: Second-generation Trials to Address Gaps in Knowledge.缺氧缺血性脑病的低温治疗：第二代试验以填补知识空白。
Clin Perinatol. 2024 Sep;51(3):587-603. doi: 10.1016/j.clp.2024.04.014. Epub 2024 May 22.
6
Brain MRI Injury Patterns across Gestational Age among Preterm Infants with Perinatal Asphyxia.围产期窒息早产儿脑 MRI 损伤模式与胎龄的关系。
Neonatology. 2024;121(5):616-626. doi: 10.1159/000538986. Epub 2024 Jun 5.
7
The influence of late prematurity on the encephalopathy exam of infants with neonatal encephalopathy.早产儿晚期对新生儿脑病患儿脑病检查的影响。
J Neonatal Perinatal Med. 2023;16(4):693-700. doi: 10.3233/NPM-230041.
8
Time to Reaching Target Cooling Temperature and 2-year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.目标降温时间与缺氧缺血性脑病婴儿 2 年结局的关系
J Pediatr. 2024 Mar;266:113853. doi: 10.1016/j.jpeds.2023.113853. Epub 2023 Nov 23.
9
Neonatal Hypoxic-Ischemic Encephalopathy and Hypothermia Treatment.新生儿缺氧缺血性脑病与低温治疗
Obstet Gynecol. 2024 Jan 1;143(1):67-81. doi: 10.1097/AOG.0000000000005392. Epub 2023 Oct 5.
10
Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network.新生儿研究网络对缺氧缺血性脑病的神经保护作用。
Semin Perinatol. 2022 Nov;46(7):151639. doi: 10.1016/j.semperi.2022.151639. Epub 2022 Jun 10.

本文引用的文献

1
Neonatal Magnetic Resonance Imaging Pattern of Brain Injury as a Biomarker of Childhood Outcomes following a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy.新生儿缺氧缺血性脑病亚低温治疗后，脑损伤的新生儿磁共振成像模式作为儿童期预后的生物标志物
J Pediatr. 2015 Nov;167(5):987-93.e3. doi: 10.1016/j.jpeds.2015.08.013. Epub 2015 Sep 16.
2
Hypothermia and neonatal encephalopathy.低体温与新生儿脑病。
Pediatrics. 2014 Jun;133(6):1146-50. doi: 10.1542/peds.2014-0899.
3
Obstetric antecedents to body-cooling treatment of the newborn infant.新生儿身体降温治疗的产科相关因素。
Am J Obstet Gynecol. 2014 Aug;211(2):155.e1-6. doi: 10.1016/j.ajog.2014.02.013. Epub 2014 Feb 13.
4
Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy.新生儿缺氧缺血性脑病亚低温治疗后脑损伤。
Arch Dis Child Fetal Neonatal Ed. 2012 Nov;97(6):F398-404. doi: 10.1136/archdischild-2011-301524.
5
Antecedents of neonatal encephalopathy in the Vermont Oxford Network Encephalopathy Registry.美国佛蒙特州牛津网络脑病注册研究中的新生儿脑病的病因。
Pediatrics. 2012 Nov;130(5):878-86. doi: 10.1542/peds.2012-0714. Epub 2012 Oct 15.
6
Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial.磁共振成像在新生儿缺氧缺血性脑病中的预后效用：一项随机试验的子研究
Arch Pediatr Adolesc Med. 2012 Jul 1;166(7):634-40. doi: 10.1001/archpediatrics.2012.284.
7
The relationship between clinically identifiable intrapartum sentinel events and short-term outcome after therapeutic hypothermia.产时临床可识别的哨兵事件与治疗性低体温后短期结局的关系。
J Pediatr. 2011 Nov;159(5):726-30. doi: 10.1016/j.jpeds.2011.04.014. Epub 2011 May 19.
8
Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial.对足月和近足月缺氧缺血性脑病新生儿进行全身低温治疗：一项随机对照试验。
Arch Pediatr Adolesc Med. 2011 Aug;165(8):692-700. doi: 10.1001/archpediatrics.2011.43. Epub 2011 Apr 4.
9
Perinatal events and early magnetic resonance imaging in therapeutic hypothermia.围产期事件与治疗性低体温的早期磁共振成像。
J Pediatr. 2011 Mar;158(3):360-5. doi: 10.1016/j.jpeds.2010.09.003. Epub 2010 Oct 20.
10
Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT.新生儿脑病后全身低温治疗：neo.NEURO.network RCT 的结果。
Pediatrics. 2010 Oct;126(4):e771-8. doi: 10.1542/peds.2009-2441. Epub 2010 Sep 20.