酪氨酸和二苯甲酮-4 的氯化产物的联合遗传毒性
Combined genotoxicity of chlorinated products from tyrosine and benzophenone-4.
机构信息
Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
出版信息
J Hazard Mater. 2017 Jan 15;322(Pt B):387-393. doi: 10.1016/j.jhazmat.2016.10.014. Epub 2016 Oct 11.
The toxicity of disinfection by-products (DBPs) from a single precursor was studied intensively. Here we examined the genotoxicity when two precursors (tyrosine (Tyr) and benzophenone-4 (BP-4)) were chlorinated together and separately. We sought to examine whether the genotoxicity of the mixture (GCM) could be estimated from the sum of the genotoxicities of the individual precursors (GCI), which were chlorinated separately. We determined the genotoxicity using the SOS/umu test. The results revealed that GCM was not identical to GCI. The difference in genotoxicity between GCM and GCI (G) was observed to decrease with increasing pH. GCM was higher than GCI (G>0) at pH 5.0-6.1, and lower than GCI (G<0) at pH 6.3-8.0. We found that nitrogen-containing DBPs played a dominant role in determining GCM and GCI. We propose that the total organic nitrogen (TON) ratio, TON/TON, is useful to estimate G.
我们深入研究了单一前体的消毒副产物（DBPs）的毒性。在这里，我们研究了两种前体（酪氨酸（Tyr）和二苯甲酮-4（BP-4））一起氯化和单独氯化时的遗传毒性。我们试图检查混合物（GCM）的遗传毒性是否可以从单独氯化的各个前体（GCI）的遗传毒性总和来估计。我们使用 SOS/umu 测试来确定遗传毒性。结果表明，GCM 与 GCI 并不相同。在不同 pH 值下，GCM 与 GCI（G）之间的遗传毒性差异观察到随着 pH 值的增加而减小。在 pH 5.0-6.1 时，GCM 高于 GCI（G>0），而在 pH 6.3-8.0 时，GCM 低于 GCI（G<0）。我们发现含氮 DBPs 在确定 GCM 和 GCI 方面起着主导作用。我们提出总有机氮（TON）比，TON/TON，可用于估计 G。
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