Ramírez-Moreno J M, Felix-Redondo F J, Fernández-Bergés D, Lozano-Mera L
Sección de Neurología, Hospital Universitario Infanta Cristina, Badajoz, España; Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad de Extremadura, Badajoz, España.
Centro de Salud Villanueva Norte, Villanueva de la Serena, Badajoz, España; Unidad de Investigación Área sanitaria de Don Benito-Villanueva, Grupo GRIMEX, Badajoz, España.
Neurologia (Engl Ed). 2018 Nov-Dec;33(9):561-569. doi: 10.1016/j.nrl.2016.09.002. Epub 2016 Oct 21.
The incidence of stroke in Spain has been evaluated in several studies, whose results are highly variable and not comparable. No studies of stroke have analysed epidemiological changes in younger patients.
We conducted a retrospective observational study using the Spanish health system's Minimum Data Set and included all patients older than 19 hospitalised due to stroke (ICD-9-CM codes 434.01, 434.11, 434.91, 430, 431, 432.9, 436, and 435) between 2002 and 2013. The analysis was performed using joinpoint regression.
A total of 39,321 patients were identified (47.25% were women); 3.73% were aged 20-44, 6.29% were 45-54, 11.49% were 55-64, 23.89% were 65-74, and 54.60% were > 74 years. The hospitalisation rate due to ischaemic stroke has increased significantly in men aged 45-54 (+6.7%; 95% CI, 3.3-10.2) and in women aged 20-44 and 45-54 (+6.1%; 95% CI, 0.8-11.7 and +5.7%; 95% CI, 3.0-8.4, respectively). We also observed a significant increase in the rate of hospitalisation due to ischaemic stroke in men aged over 74 (+4.2%; 95% CI, 1.3-7.2). The rate of hospitalisations due to transient ischaemic attack has also increased significantly whereas the rate of hospitalisations due to brain haemorrhage has stabilised over time.
Our results provide indirect evidence that the epidemiological profile of stroke is changing based on the increase in hospitalisation rates in young adults.
西班牙已在多项研究中对中风发病率进行了评估,但其结果差异很大且无可比性。尚无中风研究分析过年轻患者的流行病学变化。
我们使用西班牙医疗系统的最小数据集进行了一项回顾性观察研究,纳入了2002年至2013年间因中风住院(国际疾病分类第九版临床修订本编码434.01、434.11、434.91、430、431、432.9、436和435)的所有19岁以上患者。分析采用连接点回归法。
共识别出39321例患者(47.25%为女性);20至44岁年龄组占3.73%,45至54岁年龄组占6.29%,55至64岁年龄组占11.49%,65至74岁年龄组占23.89%,74岁以上年龄组占54.60%。45至54岁男性因缺血性中风的住院率显著上升(+6.7%;95%置信区间,3.3 - 10.2),20至44岁以及45至54岁女性因缺血性中风的住院率也显著上升(分别为+6.1%;95%置信区间,0.8 - 11.7和+5.7%;95%置信区间,3.0 - 8.4)。我们还观察到74岁以上男性因缺血性中风的住院率显著上升(+4.2%;95%置信区间,1.3 - 7.2)。因短暂性脑缺血发作的住院率也显著上升,而因脑出血的住院率随时间推移已趋于稳定。
我们的结果提供了间接证据,表明基于年轻成年人住院率的上升,中风的流行病学特征正在发生变化。