Fernandes José A L, Prandini Tâmara H R, Castro Maria da Conceiçao A, Arantes Thales D, Giacobino Juliana, Bagagli Eduardo, Theodoro Raquel C
Institute of Tropical Medicine of Rio Grande do Norte, Universidade Federal do Rio Grande do Norte Natal, Brazil.
Department of Microbiology and Immunology, Institute of Biosciences, Universidade Estadual Paulista Julio de Mesquita Filho Botucatu, Brazil.
Front Microbiol. 2016 Oct 10;7:1585. doi: 10.3389/fmicb.2016.01585. eCollection 2016.
Inteins are invasive intervening sequences that perform an autocatalytic splicing from their host proteins. Among eukaryotes, these elements are present in many fungal species, including those considered opportunistic or primary pathogens, such as spp. Here we reviewed and updated the list of species containing inteins in the genes and and pointed out the importance of these elements as molecular markers for molecular epidemiological researches and species-specific diagnosis, since the presence, as well as the size of these inteins, is polymorphic among the different species. Although absent in , these elements are present in different sizes, in some environmental spp. and also in most of the non-albicans spp. considered emergent opportunistic pathogens. Besides, the possible role of these inteins in yeast physiology was also discussed in the light of the recent findings on the importance of these elements as post-translational modulators of gene expression, reinforcing their relevance as alternative therapeutic targets for the treatment of non-albicans infections, because, once the splicing of an intein is inhibited, its host protein, which is usually a housekeeping protein, becomes non-functional.
内含肽是能够从其宿主蛋白中进行自我催化剪接的侵入性间隔序列。在真核生物中，这些元件存在于许多真菌物种中，包括那些被认为是机会性或原发性病原体的物种，如 属物种。在这里，我们回顾并更新了在基因 和 中含有内含肽的 物种列表，并指出了这些元件作为分子流行病学研究和物种特异性诊断的分子标记的重要性，因为这些内含肽的存在及其大小在不同物种之间是多态性的。虽然在 中不存在，但这些元件在一些环境 属物种以及大多数被认为是新兴机会性病原体的非白色念珠菌 属物种中以不同大小存在。此外，根据最近关于这些元件作为基因表达的翻译后调节剂的重要性的研究结果，还讨论了这些内含肽在酵母生理学中的可能作用，这进一步强调了它们作为治疗非白色念珠菌感染的替代治疗靶点的相关性，因为一旦内含肽的剪接被抑制，其宿主蛋白（通常是一种管家蛋白）就会失去功能。
