Wdowiak Artur
Diagnostic Techniques Unit, Department of Health Sciences, Medical University of Lublin, Lublin, Poland.
Int J Endocrinol. 2016;2016:6273298. doi: 10.1155/2016/6273298. Epub 2016 Sep 29.
The aim of this study was to investigate the activity of myoinositol, in a court of 217 PCOS women undergoing intracytoplasmic sperm injection (ICSI), on pregnancy rate, embryo development, estradiol, and progesterone concentration in blood serum, superoxide dismutase (SOD), and catalase (CAT) in follicular fluid. Concerning the court of patient, 112 (groups I and II) out of 217 were PCOS women, whereas group III consisted of healthy subjects (not PCOS). Group I patients were treated with 400 g of folic acid per day for 3 months before ICSI, whereas group II patients received 4000 mg of myoinositol and 400 g of folic acid per day for 3 months before ICSI. Group II revealed a shorter embryo/blastocyst development period between microinjection and 5-cell stage compared to group I. The difference in SOD concentration between groups I and II and between groups II and III was statistically significant. In group II, 34.62% of pregnancies were obtained, whereas in group I this number reached 20% (NS). Myoinositol increased embryo development dynamics and accelerated blastocyst stage reaching time; however, no effect was shown on clinical pregnancy. Furthermore, it restored SOD concentration, lowered in PCOS women, but did not exert any effect on CAT concentration.
本研究的目的是在217名接受卵胞浆内单精子注射（ICSI）的多囊卵巢综合征（PCOS）女性中，调查肌醇对妊娠率、胚胎发育、血清雌二醇和孕酮浓度、卵泡液中超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性的影响。在患者群体方面，217名中有112名（第一组和第二组）为PCOS女性，而第三组由健康受试者（非PCOS）组成。第一组患者在ICSI前3个月每天接受400μg叶酸治疗，而第二组患者在ICSI前3个月每天接受4000mg肌醇和400μg叶酸治疗。与第一组相比，第二组在显微注射至5细胞阶段之间的胚胎/囊胚发育时间更短。第一组和第二组之间以及第二组和第三组之间的SOD浓度差异具有统计学意义。在第二组中，妊娠率为34.62%，而在第一组中这一数字为20%（无统计学差异）。肌醇增加了胚胎发育动态并加速了囊胚阶段的到达时间；然而，对临床妊娠没有影响。此外，它恢复了PCOS女性中降低的SOD浓度，但对CAT浓度没有任何影响。
