Liu Yi-Han, Kong Wei
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.
Sheng Li Xue Bao. 2016 Oct 25;68(5):592-610.
Vascular calcification is an active, invertible and highly regulated pathophysiological process, characterized by the deposition of hydroxyapatite crystal in vascular wall. Vascular calcification is classified into two types based on the sites of calcification: intimal atherosclerotic calcification and Mönckeberg's medial calcification. Medial vascular calcification is a pathological phenomenon commonly existed in diabetes, chronic kidney failure and aging. The current review summarizes the mechanisms of medial vascular calcification.
血管钙化是一个活跃、可逆且高度受调控的病理生理过程,其特征是羟基磷灰石晶体在血管壁沉积。根据钙化部位,血管钙化可分为两种类型:内膜动脉粥样硬化钙化和蒙克贝格中膜钙化。中膜血管钙化是糖尿病、慢性肾衰竭和衰老中常见的病理现象。本综述总结了中膜血管钙化的机制。