University of Antwerp, Department of Pathophysiology, Universiteitsplein 1, Wilrijk, Belgium.
Circ Res. 2011 Jan 21;108(2):249-64. doi: 10.1161/CIRCRESAHA.110.225904.
Accelerated atherosclerotic plaque calcification and extensive medial calcifications are common and highly detrimental complications of chronic kidney disease. Valid murine models have been developed to investigate both pathologically distinguishable complications, which allow for better insight into the cellular mechanisms underlying these vascular pathologies and evaluation of compounds that might prevent or retard the onset or progression of vascular calcification. This review describes various experimental models that have been used for the study of arterial intimal and/or medial calcification and discusses the extent to which this experimental research has contributed to our current understanding of vascular calcification, particularly in the setting of chronic renal failure.
加速的动脉粥样硬化斑块钙化和广泛的中膜钙化是慢性肾脏病的常见且高度有害的并发症。已经开发出有效的小鼠模型来研究这两种在病理学上可区分的并发症，这有助于更好地了解这些血管病变的细胞机制，并评估可能预防或延缓血管钙化发生或进展的化合物。本文综述了用于研究动脉内膜和/或中膜钙化的各种实验模型，并讨论了这些实验研究在多大程度上促进了我们对血管钙化的理解，特别是在慢性肾衰竭的背景下。
