寻常型扁平苔藓与人类疱疹病毒7型感染的关联。
Association of classic lichen planus with human herpesvirus-7 infection.
作者信息
Nahidi Yalda, Tayyebi Meibodi Naser, Ghazvini Kiarash, Esmaily Habibollah, Esmaeelzadeh Maryam
机构信息
Cutaneous Leishmaniasis Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad, Iran.
Research Center for Microbiology and Virology, Imam Reza Hospital, Faculty of Medicine, Mashhad, Iran.
出版信息
Int J Dermatol. 2017 Jan;56(1):49-53. doi: 10.1111/ijd.13416. Epub 2016 Oct 25.
BACKGROUND
Lichen planus is a mucocutaneous papulosquamous itchy disease with unknown etiology. A number of factors such as immune mechanisms, viral agents, and drugs have been implicated in pathogenesis of lichen planus. In recent years, several studies have indicated the role of viral agents in this disease, including human herpesvirus-7 (HHV-7). Studies have given contradictory results, which is why we decided to study the possible association between lichen planus with HHV-7.
METHODS
In this case-control study, which was conducted on 60 cutaneous classic lichen planus samples as well as 60 healthy control skin samples after matching the two groups in terms of gender and age, tissue samples of patients and controls were studied by real time polymerase chain reaction to detect for HHV-7.
RESULTS
According to this study, HHV-7 DNA was found in 18 samples of the case group (30.0%) and in six (10.0%) of the control group (P = 0.006).
CONCLUSION
The results of this study support the likely role of HHV-7 in pathogenesis of lichen planus. As an exogenous antigen, this virus may be involved in cellular immune-mediated destruction of keratinocytes.
背景
扁平苔藓是一种病因不明的黏膜皮肤丘疹鳞屑性瘙痒性疾病。免疫机制、病毒因子和药物等多种因素与扁平苔藓的发病机制有关。近年来，多项研究表明病毒因子在该病中的作用，包括人类疱疹病毒7型（HHV-7）。研究结果相互矛盾，这就是我们决定研究扁平苔藓与HHV-7之间可能关联的原因。
方法
在这项病例对照研究中，对60例皮肤经典型扁平苔藓样本以及60例健康对照皮肤样本进行研究，两组在性别和年龄方面匹配后，通过实时聚合酶链反应对患者和对照的组织样本进行检测以检测HHV-7。
结果
根据本研究，病例组18个样本（30.0%）中发现HHV-7 DNA，对照组6个样本（10.0%）中发现（P = 0.006）。
结论
本研究结果支持HHV-7在扁平苔藓发病机制中可能发挥的作用。作为一种外源性抗原，该病毒可能参与细胞免疫介导的角质形成细胞破坏。
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