外伤性脉络膜破裂后视网膜色素上皮的伤口愈合
Retinal pigment epithelium wound healing after traumatic choroidal rupture.
作者信息
Shin Joo Youn, Chung Byunghoon, Na Yun Hyup, Lee Jonghyun, Chung Hyewon, Byeon Suk Ho
机构信息
Department of Ophthalmology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea.
Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea.
出版信息
Acta Ophthalmol. 2017 Nov;95(7):e582-e586. doi: 10.1111/aos.13300. Epub 2016 Oct 24.
PURPOSE
The aim of this study was to investigate wound healing in the retinal pigment epithelium (RPE) after traumatic indirect choroidal rupture using fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT).
METHODS
A total of 14 eyes of 14 patients with traumatic indirect choroidal rupture were included. Baseline and last follow-up FAF images were compared to evaluate the extent of RPE healing after choroidal rupture, and associated morphologic characteristics were examined by SD-OCT.
RESULTS
The size of the RPE lesion was reduced in five eyes. The change occurred in the fovea in four eyes and in the macula in three eyes. The change was noted in both the fovea and the macula in two eyes; in these cases, the changes were more prominent in the fovea than in the macula. Extra-macular lesions and lesions with deep choroidal involvement did not show any reduction in size. Choroidal neovascularization (CNV) developed in seven eyes. There was no extra-macular CNV.
CONCLUSION
Retinal pigment epithelium (RPE) wound healing after traumatic choroidal rupture is affected by location and extent of the lesion.
目的
本研究旨在利用眼底自发荧光（FAF）和光谱域光学相干断层扫描（SD-OCT）研究外伤性间接脉络膜破裂后视网膜色素上皮（RPE）的伤口愈合情况。
方法
纳入14例患有外伤性间接脉络膜破裂患者的14只眼。比较基线和末次随访时的FAF图像，以评估脉络膜破裂后RPE愈合的程度，并通过SD-OCT检查相关的形态学特征。
结果
5只眼中RPE病变的大小减小。4只眼的病变发生在黄斑中心凹，3只眼的病变发生在黄斑区。2只眼的黄斑中心凹和黄斑区均有变化；在这些病例中，黄斑中心凹的变化比黄斑区更明显。黄斑外病变和累及脉络膜深层的病变大小未出现任何减小。7只眼发生了脉络膜新生血管（CNV）。未出现黄斑外CNV。
结论
外伤性脉络膜破裂后视网膜色素上皮（RPE）伤口愈合受病变部位和范围的影响。
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