循环肿瘤细胞作为肺癌诊断的潜在生物标志物：一项系统评价与荟萃分析
Circulating tumor cells as a potential biomarker in diagnosis of lung cancer: a systematic review and meta-analysis.
作者信息
Huang Huang, Shi Yan, Huang Jietao, Wang Xiaohui, Zhang Rui, Chen Hong
机构信息
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, China.
Chinese Orthopaedics and Traumatology, Heilongjiang University of Chinese Medicine, China.
出版信息
Clin Respir J. 2018 Feb;12(2):639-645. doi: 10.1111/crj.12573. Epub 2016 Nov 10.
OBJECTIVES
Accumulating evidences demonstrated that circulating tumor cells (CTCs) show significant high concentration in plasma of lung cancer patients compared to control cohorts, suggesting that CTCs may be a promising biomarker for lung cancer. The meta-analysis was used to evaluate potential diagnostic value of CTCs in diagnosing lung cancer.
METHODS
Relevant literatures were searched in PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang Data. Summary estimates were used to evaluate CTCs as the diagnostic standard for lung cancer using Meta-DiSc and STATA 12.0 statistical software.
RESULTS
This meta-analysis included five studies with a total of 460 lung cancer patients and 239 benign controls. The sensitivity and specificity (95% confidence interval [CI]) of CTCs was 75% (95% CI: 54%-88%) and 92% (95%CI: 82%-97%), respectively. In addition, the area under the summary ROC curve (AUC) was 0.93.
CONCLUSION
CTCs is a novel potential biomarker in the diagnosis of lung cancer, and more prospective are needed in the future.
目的
越来越多的证据表明，与对照组相比，肺癌患者血浆中循环肿瘤细胞（CTC）的浓度显著升高，这表明CTC可能是一种有前景的肺癌生物标志物。本荟萃分析旨在评估CTC在肺癌诊断中的潜在诊断价值。
方法
在PubMed、Embase、Cochrane图书馆、中国生物医学文献数据库（CBM）、中国知网（CNKI）、维普资讯（VIP）和万方数据中检索相关文献。使用Meta-DiSc和STATA 12.0统计软件，采用汇总估计量评估CTC作为肺癌诊断标准的情况。
结果
本荟萃分析纳入了5项研究，共460例肺癌患者和239例良性对照。CTC的敏感性和特异性（95%置信区间[CI]）分别为75%（95%CI：54%-88%）和92%（95%CI：82%-97%）。此外，汇总ROC曲线下面积（AUC）为0.93。
结论
CTC是肺癌诊断中一种新型的潜在生物标志物，未来还需要更多的前瞻性研究。
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