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脊髓损伤后神经原性下尿路功能障碍的管理。

The management of neurogenic lower urinary tract dysfunction after spinal cord injury.

机构信息

University of Antwerp, Antwerp, SIRATE32 GCV, Bredabaan 32, 2930 Brasschaat, Belgium.

出版信息

Nat Rev Urol. 2016 Dec;13(12):705-714. doi: 10.1038/nrurol.2016.206. Epub 2016 Oct 25.

DOI:10.1038/nrurol.2016.206
PMID:27779229
Abstract

The management of patients with neurogenic bladder has changed substantially over the past decades. Obtaining balanced lower urinary tract function has become possible in most patients, although, urological complications remain among the most serious complications these patients are likely to have and, even today, these can have a negative effect on quality of life. To this extent, patients with spinal cord injury (SCI) are likely to develop neurogenic bladder, and data are available on most aspects of neurogenic bladder in these patients. Data on physiology and pathophysiology form the basis of our understanding of patients' symptoms, and also provide a basis for the management of these patients. The use of conservative, and/or more invasive treatment measures, their complications and measures to prevent these complications, are all important clinical aspects that merit discussion. Considerable progress has been made in the urological management of patients with SCI over the past decades, but opportunities remain to make diagnosis more accurate and therapy more successful.

摘要

过去几十年来,神经源性膀胱患者的管理发生了重大变化。大多数患者的下尿路功能已经可以达到平衡,尽管泌尿系统并发症仍然是这些患者最严重的并发症之一,即使在今天,这些并发症仍会对生活质量产生负面影响。在这方面,脊髓损伤(SCI)患者很可能会出现神经源性膀胱,并且针对这些患者的神经源性膀胱的大多数方面都有相关数据。生理学和病理生理学数据为我们了解患者的症状提供了基础,也为这些患者的管理提供了依据。保守治疗和/或更具侵袭性的治疗措施的使用、它们的并发症以及预防这些并发症的措施都是值得讨论的重要临床方面。在过去几十年中,SCI 患者的泌尿系统管理取得了相当大的进展,但仍有机会使诊断更准确,治疗更成功。

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Initial experience with the treatment of neurogenic detrusor overactivity with a new β-3 agonist (mirabegron) in patients with spinal cord injury.脊髓损伤患者使用新型β-3激动剂(米拉贝隆)治疗神经源性逼尿肌过度活动的初步经验。
Spinal Cord. 2016 Jan;54(1):78-82. doi: 10.1038/sc.2015.195. Epub 2015 Oct 27.
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