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开始接受芳香化酶抑制剂治疗的黑人和白人乳腺癌患者的心血管健康状况

Cardiovascular Health among Black and White Breast Cancer Patients Initiating Aromatase Inhibitor Therapy.

作者信息

Gallicchio Lisa, Calhoun Carla, Riseberg David, Helzlsouer Kathy

机构信息

The Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

出版信息

Breast J. 2017 Mar;23(2):206-209. doi: 10.1111/tbj.12709. Epub 2016 Oct 25.

Abstract

The purpose of this study was to compare the cardiovascular health of Black and White breast cancer patients undergoing adjuvant treatment. Baseline data from a cohort study of Black (n = 45) and White (n = 101) breast cancer patients initiating aromatase inhibitor treatment were analyzed. Participants had a cardiovascular health assessment, including carotid intimal medial thickness measurement, donated a blood sample, and completed a questionnaire. Atherosclerotic cardiovascular disease (ASCVD) event risk scores were calculated. Compared to their White counterparts, the Black patients had a significantly higher median ASCVD risk score (p = 0.009) and had a higher number of CVD risk factors (p < 0.05). Black patients were also more likely to have hypertension, diabetes, or to be obese than the White participants. The prevalence of cardiovascular disease and cardiovascular disease risk factors among Black and White breast cancer patients is high, and racial disparities exist which may have treatment implications.

摘要

本研究的目的是比较接受辅助治疗的黑人与白人乳腺癌患者的心血管健康状况。对一项针对开始接受芳香化酶抑制剂治疗的黑人(n = 45)和白人(n = 101)乳腺癌患者的队列研究的基线数据进行了分析。参与者接受了心血管健康评估,包括颈动脉内膜中层厚度测量,捐献了血样,并完成了一份问卷。计算了动脉粥样硬化性心血管疾病(ASCVD)事件风险评分。与白人患者相比,黑人患者的ASCVD风险评分中位数显著更高(p = 0.009),且心血管疾病风险因素数量更多(p < 0.05)。黑人患者患高血压、糖尿病或肥胖的可能性也高于白人参与者。黑人和白人乳腺癌患者中心血管疾病和心血管疾病风险因素的患病率很高,并且存在种族差异,这可能对治疗有影响。

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