Gepner Adam D, Colangelo Laura A, Reilly Nicole, Korcarz Claudia E, Kaufman Joel D, Stein James H
Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
PLoS One. 2015 Nov 6;10(11):e0142138. doi: 10.1371/journal.pone.0142138. eCollection 2015.
Associations between carotid artery longitudinal displacement, cardiovascular disease risk factors, and events were evaluated in a large, multi-ethnic cohort.
A novel, reproducible protocol was developed for measuring right common carotid artery longitudinal displacement using ultrasound speckle-tracking. Total longitudinal displacement was measured in 389 randomly selected participants from the Multi-Ethnic Study of Atherosclerosis that were free of cardiovascular disease at baseline. Univariate analyses and Pearson Correlations were used to define relationships between longitudinal displacement with traditional cardiovascular risk factors and traditional measures of arterial stiffness. Hazard ratios of longitudinal displacement for cardiovascular disease and coronary heart disease events were compared using Cox proportional hazards models.
Participants were a mean (standard deviation) 59.0 (8.7) years old, 48% female, 39% White, 26% Black, 22% Hispanic, and 14% Chinese. They had 19 (4.9%) cardiovascular disease and 14 (3.6%) coronary heart disease events over a mean 9.5 years of follow-up. Less longitudinal displacement was associated with Chinese (β = -0.11, p = 0.02) compared to White race/ethnicity and greater longitudinal displacement was associated with higher carotid intima-media thickness (β = 0.26, p = 0.004). Longitudinal displacement was not associated with other cardiovascular disease risk factors or markers of arterial stiffness. After adjustment for age and sex, and heart rate, Chinese race/ethnicity (β = -0.10, p = 0.04) and carotid intima-media thickness (β = 0.30 p = 0.003) were associated independently with longitudinal displacement. Longitudinal displacement predicted coronary heart disease (Hazard ratio [HR] 3.3, 95% Confidence intervals [CI] 0.96-11.14, p = 0.06) and cardiovascular disease (HR 2.1, 95% CI 0.6-7.3, p = 0.23) events.
Less longitudinal displacement is associated with Chinese ethnicity and greater carotid artery longitudinal displacement is associated with thicker intima-media thickness. Longitudinal displacement may predict adverse coronary heart disease and cardiovascular disease events.
在一个大型多民族队列中评估了颈动脉纵向位移、心血管疾病风险因素和事件之间的关联。
开发了一种新颖的、可重复的方案，用于使用超声斑点追踪测量右颈总动脉纵向位移。在来自动脉粥样硬化多民族研究的389名随机选择的参与者中测量了总纵向位移，这些参与者在基线时无心血管疾病。使用单变量分析和Pearson相关性来定义纵向位移与传统心血管风险因素以及动脉僵硬度传统测量指标之间的关系。使用Cox比例风险模型比较心血管疾病和冠心病事件的纵向位移风险比。
参与者的平均（标准差）年龄为59.0（8.7）岁，48%为女性，39%为白人，26%为黑人，22%为西班牙裔，14%为华裔。在平均9.5年的随访中，他们发生了19例（4.9%）心血管疾病和14例（3.6%）冠心病事件。与白人种族/民族相比，华裔的纵向位移较少（β = -0.11，p = 0.02），而较大的纵向位移与较高的颈动脉内膜中层厚度相关（β = 0.26，p = 0.004）。纵向位移与其他心血管疾病风险因素或动脉僵硬度标志物无关。在调整年龄、性别和心率后，华裔种族/民族（β = -0.10，p = 0.04）和颈动脉内膜中层厚度（β = 0.30，p = 0.003）与纵向位移独立相关。纵向位移可预测冠心病（风险比[HR] 3.3，95%置信区间[CI] 0.96 - 11.14，p = 0.06）和心血管疾病（HR 2.1，95% CI 0.6 - 7.3，p = 0.23）事件。
较少的纵向位移与华裔相关，而较大的颈动脉纵向位移与较厚的内膜中层厚度相关。纵向位移可能预测不良的冠心病和心血管疾病事件。
