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[勘误] 基因和表观遗传改变参与胆管癌中TPM1的调控。

[Corrigendum] Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma.

作者信息

Yang Wei, Wang Xiaoyuan, Zheng Wei, Li Kedong, Liu Haofeng, Sun Yueming

机构信息

Department of Minimally Invasive Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.

出版信息

Int J Oncol. 2017 Jan;50(1):340. doi: 10.3892/ijo.2016.3749. Epub 2016 Oct 24.

DOI:10.3892/ijo.2016.3749
PMID:27779677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5182001/
Abstract

Following the publication of this article, an interested reader drew to our attention anomalies associated with the data shown in Fig. 2, which presented the mRNA and protein expression levels of tropomyosin 1 (TPM1) in HuCCT1 cells. Essentially, the control bands for α-tubulin had been duplicated across from Fig. 2A to Fig. 2B, and from Fig. 2D to Fig. 2E [the experiments showing treatment of the cells with (A) manumycin A, (B) U0126, (D) 5-aza-2-deoxycytidine (DAC) and (E) trichostatin A (TSA)], respectively. After having re‑examined our original data, we realize that the figure was compiled incorrectly, and have returned to our source data. A corrected version of Fig. 2 is presented here, showing the correct control α-tubulin data for Fig. 2A and E, as they ought to have appeared. This error did not overall affect the conclusions reported in the study. We sincerely apologize for this mistake, and thank the reader of our article who drew this matter to our attention. Furthermore, we regret any inconvenience this mistake has caused. [the original article was published in the International Journal of Oncology 42: 690-698, 2013; DOI: 10.3892/ijo.2012.1741].

摘要

在本文发表之后,一位感兴趣的读者让我们注意到与图2所示数据相关的异常情况,图2展示了HuCCT1细胞中肌动蛋白1(TPM1)的mRNA和蛋白质表达水平。实际上,α-微管蛋白的对照条带从图2A复制到了图2B,以及从图2D复制到了图2E [这些实验分别展示了用(A)手霉素A、(B)U0126、(D)5-氮杂-2'-脱氧胞苷(DAC)和(E)曲古抑菌素A(TSA)处理细胞的情况]。在重新检查我们的原始数据后,我们意识到该图编制有误,现已找回我们的源数据。此处展示了图2的修正版本,显示了图2A和E正确的α-微管蛋白对照数据,即它们应呈现的样子。这个错误总体上并未影响该研究报告的结论。我们为这个错误真诚道歉,并感谢提醒我们注意此事的文章读者。此外,我们对这个错误造成的任何不便表示遗憾。[原文发表于《国际肿瘤学杂志》42: 690 - 698,2013;DOI: 10.3892/ijo.2012.1741]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb87/5182001/1f0710feb978/IJO-50-01-0340-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb87/5182001/1f0710feb978/IJO-50-01-0340-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb87/5182001/1f0710feb978/IJO-50-01-0340-g00.jpg

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