Valaperta Rea, Gaeta Maddalena, Cardani Rosanna, Lombardi Fortunata, Rampoldi Benedetta, De Siena Claudia, Mori Francesca, Fossati Barbara, Gaia Paola, Ferraro Ottavia Eleonora, Villani Simona, Iachettini Sara, Piccoli Marco, Cirillo Federica, Pusineri Enrico, Meola Giovanni, Costa Elena
Research Laboratories, IRCCS Policlinico San Donato, San Donato Milanese, Italy; Service of Laboratory Medicine, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
Department of Public Health, Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, Unit of Hygiene, University of Pavia, Italy.
Clin Chim Acta. 2016 Dec 1;463:122-128. doi: 10.1016/j.cca.2016.10.026. Epub 2016 Oct 22.
Myotonic dystrophy (DM) is a genetic disorder caused by nucleotide repeats expansion. Sudden death represents the main cause of mortality in DM patients. Here, we investigated the relationship between serum cardiac biomarkers with clinical parameters in DM patients.
Case-control study included 59 DM patients and 22 healthy controls. An additional group of 62 controls with similar cardiac defects to DM were enrolled.
NT-proBNP, hs-cTnT and CK levels were significantly increased in DM patients compared to healthy subjects (p=0.0008, p<0.0001, p<0.0001). Also, hs-cTnT levels were significantly higher in DM compared to control group with cardiac defects (p=0.0003). Positive correlation was found between hs-cTnT and hs-cTnI in both DM patients and controls (p=0.019, p=0.002). Independently from the age, the risk of DM disease was positively related to an increase in hs-cTnT (p=0.03). On the contrary, the risk of DM was not related to hs-cTnI, but was evidenced a role of PR interval (p=0.03) and CK (p=0.08).
The levels of hs-cTnT were significantly higher in DM patients. Analysis, with anti-cTnT, shows that this increase might be linked to heart problems. This last finding suggests that hs-cTnT might represent a helpful serum biomarker to "predict" cardiac risk in DM disease.
强直性肌营养不良（DM）是一种由核苷酸重复序列扩增引起的遗传性疾病。猝死是DM患者的主要死亡原因。在此，我们研究了DM患者血清心脏生物标志物与临床参数之间的关系。
病例对照研究纳入了59例DM患者和22例健康对照。另外纳入了62例有与DM相似心脏缺陷的对照。
与健康受试者相比，DM患者的N末端B型利钠肽原（NT-proBNP）、高敏心肌肌钙蛋白T（hs-cTnT）和肌酸激酶（CK）水平显著升高（p = 0.0008，p < 0.0001，p < 0.0001）。此外，与有心脏缺陷的对照组相比，DM患者的hs-cTnT水平显著更高（p = 0.0003）。在DM患者和对照组中，hs-cTnT与高敏心肌肌钙蛋白I（hs-cTnI）之间均发现正相关（p = 0.019，p = 0.002）。独立于年龄，DM疾病风险与hs-cTnT升高呈正相关（p = 0.03）。相反，DM风险与hs-cTnI无关，但PR间期（p = 0.03）和CK（p = 0.08）显示出一定作用。
DM患者的hs-cTnT水平显著更高。用抗cTnT进行分析表明，这种升高可能与心脏问题有关。这一最新发现表明，hs-cTnT可能是“预测”DM疾病心脏风险的一种有用的血清生物标志物。
