Moon Ji In, Park Ji Young, Jeon Tae Joo, Choi Jung Min, Shin Won Chang, Sung June Min, Kim Young Moon, Kim Hyun Jung
Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2016 Oct 25;68(4):221-224. doi: 10.4166/kjg.2016.68.4.221.
Non-umbilical cutaneous metastases from pancreatic adenocarcinomas are extremely rare. Only a few cases have been reported in the literature. An 83-year-old Korean woman, with no previous medical history, presented with a painful nodule on her scalp. Histologic examination of the nodule revealed a metastatic adenocarcinoma, and immunohistochemical staining was positive for cytokeratin (CK) 7 and CK 19. These findings were consistent with a metastatic carcinoma of pancreatic origin. An abdominal computed tomography scan identified a mass on the pancreatic head and multiple enlarged lymph nodes. Pathological examination of an endoscopic ultrasound-guided fine needle biopsy of the pancreatic mass determined that it was a poorly differentiated carcinoma. The patient refused any treatment owing to her old age and short life expectancy. Four months later, the disease progressed rapidly, and the patient died.
胰腺腺癌的非脐部皮肤转移极为罕见。文献中仅报道过少数病例。一名83岁的韩国女性，既往无病史，头皮出现一个疼痛性结节。对该结节进行组织学检查发现为转移性腺癌，免疫组化染色细胞角蛋白（CK）7和CK 19呈阳性。这些结果符合胰腺来源的转移性癌。腹部计算机断层扫描显示胰头有一个肿块以及多个肿大淋巴结。对胰腺肿块进行内镜超声引导下细针穿刺活检的病理检查确定为低分化癌。由于患者年事已高且预期寿命短，拒绝了任何治疗。四个月后，病情迅速进展，患者死亡。
