黄曲霉毒素对雏鸡免疫系统的影响。

Effects of aflatoxin on the immune system of the chick.

作者信息

Virdi J S, Tiwari R P, Saxena M, Khanna V, Singh G, Saini S S, Vadehra D V

机构信息

Department of Microbiology, Panjab University, Chandigarh, India.

出版信息

J Appl Toxicol. 1989 Aug;9(4):271-5. doi: 10.1002/jat.2550090412.

DOI:10.1002/jat.2550090412

PMID:2778263

Abstract

A decreased antibody response to injected sheep red blood cells and weight losses to the extent of 25-38% were observed in the bursa Fabricii and thymus in chicks fed an aflatoxin diet (10% w/w) for 3 weeks. The immune organs did not show any significant histopathological changes. The antibody titre decreased from day 6 of treatment onward until the 15th day, when the antibody titre had disappeared completely in the test chicks. The body weight gain was also less in test chicks (9.7-37.3%) given test feed or test feed along with Salmonella pullorum in water (10(8) cfu ml 1) in comparison to chicks given toxin-free diet and water after 3 weeks of feeding trials. The disappearing component in the test chicks' liver homogenate was found to be antigenic by immunoelectrophoretic studies.

摘要

在给雏鸡饲喂黄曲霉毒素日粮（10% w/w）3周后，观察到其对注射的绵羊红细胞的抗体反应降低，法氏囊和胸腺重量减轻25% - 38%。免疫器官未显示任何明显的组织病理学变化。抗体滴度从治疗第6天开始下降，直至第15天，此时试验雏鸡的抗体滴度完全消失。与饲喂3周无毒素日粮和水的雏鸡相比，给予试验饲料或试验饲料并同时在水中添加鸡白痢沙门氏菌（10⁸ cfu/ml）的试验雏鸡体重增加也较少（9.7% - 37.3%）。通过免疫电泳研究发现，试验雏鸡肝脏匀浆中的消失成分具有抗原性。