Li Di, Xu Weiguo, Li Pengqiang, Ding Jianxun, Cheng Zhiliang, Chen Li, Yan Lesan, Chen Xuesi
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, P. R. China.
Department of Chemistry, Northeast Normal University , Changchun 130024, P. R. China.
Mol Pharm. 2016 Dec 5;13(12):4231-4235. doi: 10.1021/acs.molpharmaceut.6b00747. Epub 2016 Oct 31.
Self-targetability is an emerging targeting strategy for polymer nanocarriers with facile preparation and high targeting efficiency. An acid-sensitive dextran-doxorubicin prodrug (Dex-g-DOX) has been synthesized and used as a self-targeted drug delivery system for the treatment of orthotopic hepatoma. The polysaccharide prodrug exhibits ultraselective accumulation in cancerous liver tissue, acid-sensitive DOX release within cells, and high antitumor efficacy in vitro and in vivo. Therefore, Dex-g-DOX demonstrates great potential for chemotherapy of orthotopic hepatoma.
自靶向性是一种新兴的聚合物纳米载体靶向策略，具有制备简便和靶向效率高的特点。一种酸敏性葡聚糖-阿霉素前药（Dex-g-DOX）已被合成，并用作原位肝癌治疗的自靶向给药系统。这种多糖前药在癌性肝组织中表现出超选择性积累、细胞内酸敏性阿霉素释放以及体外和体内的高抗肿瘤疗效。因此，Dex-g-DOX在原位肝癌化疗方面显示出巨大潜力。
